잠시만 기다려 주세요. 로딩중입니다.

Laboratory Aspects of Donor Screening for Fecal Microbiota Transplantation at a Korean Fecal Microbiota Bank

Annals of Laboratory Medicine 2021년 41권 4호 p.424 ~ 428
서현수, 진형선, 김연희, 문혜수, 김경남, Nguyen Le Phuong, 용동은,
소속 상세정보
서현수 ( Seo Hyun-Soo ) - Yonsei University College of Medicine Department of Laboratory Medicine
진형선 ( Chin Hyung-Sun ) - Yonsei University College of Medicine Department of Laboratory Medicine
김연희 ( Kim Yeon-Hee ) - Yonsei University College of Medicine Department of Laboratory Medicine
문혜수 ( Moon Hye-Su ) - Yonsei University College of Medicine Department of Laboratory Medicine
김경남 ( Kim Kyung-Nam ) - Yonsei University College of Medicine Department of Laboratory Medicine
 ( Nguyen Le Phuong ) - Yonsei University College of Medicine Department of Laboratory Medicine
용동은 ( Yong Dong-Eun ) - Yonsei University College of Medicine Department of Laboratory Medicine

Abstract


Fecal microbiota transplantation (FMT) is a widely accepted alternative therapy for Clostridioides difficile infection and other gastrointestinal disorders. Thorough donor screening is required as a safety control measure to minimize transmission of infectious agents in FMT. We report the donor screening process and outcomes at a fecal microbiota bank in Korea. From August 2017 to June 2020, the qualification of 62 individuals as FMT donors was evaluated using clinical assessment and laboratory tests. Forty-six (74%) candidates were excluded after clinical assessment; high body mass index (>25) was the most common reason for exclusion, followed by atopy, asthma, and allergy history. Four of the remaining 16 (25%) candidates failed to meet laboratory test criteria, resulting in a 19% qualification rate. FMT donor re-qualification was conducted monthly as an additional safety control measure, and only three (5%) candidates were eligible for repeated donation. As high prevalence of multidrug-resistant organisms (55%) and Helicobacter pylori (44%) were detected in qualified donors during the screening, a urea breath test was added to the existing protocol. The present results emphasize the importance of implementing a donor re-qualification system to minimize risk factors not identified during initial donor screening.

키워드

Korea; Fecal microbiota transplantation; Fecal microbiota bank; Donor screening

원문 및 링크아웃 정보

등재저널 정보