잠시만 기다려 주세요. 로딩중입니다.

Relationship between serum total carbon dioxide concentration and bicarbonate concentration in patients undergoing hemodialysis

Kidney Research and Clinical Practice 2020년 39권 4호 p.441 ~ 450
Hirai Keiji, Ookawara Susumu, Morino Junki, Minato Saori, Kaneko Shohei, Yanai Katsunori, Ishii Hiroki, Matsuyama Momoko, Kitano Taisuke, Shindo Mitsutoshi, Miyazawa Haruhisa, Ito Kiyonori, Ueda Yuichirou, Watano Tatsuro, Fujino Shinji, Omoto Kiyoka, Morishita Yoshiyuki,
소속 상세정보
 ( Hirai Keiji ) - Jichi Medical University Saitama Medical Center First Department of Integrated Medicine Division of Nephrology
 ( Ookawara Susumu ) - Jichi Medical University Saitama Medical Center First Department of Integrated Medicine Division of Nephrology
 ( Morino Junki ) - Jichi Medical University Saitama Medical Center First Department of Integrated Medicine Division of Nephrology
 ( Minato Saori ) - Jichi Medical University Saitama Medical Center First Department of Integrated Medicine Division of Nephrology
 ( Kaneko Shohei ) - Jichi Medical University Saitama Medical Center First Department of Integrated Medicine Division of Nephrology
 ( Yanai Katsunori ) - Jichi Medical University Saitama Medical Center First Department of Integrated Medicine Division of Nephrology
 ( Ishii Hiroki ) - Jichi Medical University Saitama Medical Center First Department of Integrated Medicine Division of Nephrology
 ( Matsuyama Momoko ) - Jichi Medical University Saitama Medical Center First Department of Integrated Medicine Division of Nephrology
 ( Kitano Taisuke ) - Jichi Medical University Saitama Medical Center First Department of Integrated Medicine Division of Nephrology
 ( Shindo Mitsutoshi ) - Jichi Medical University Saitama Medical Center First Department of Integrated Medicine Division of Nephrology
 ( Miyazawa Haruhisa ) - Jichi Medical University Saitama Medical Center First Department of Integrated Medicine Division of Nephrology
 ( Ito Kiyonori ) - Jichi Medical University Saitama Medical Center First Department of Integrated Medicine Division of Nephrology
 ( Ueda Yuichirou ) - Jichi Medical University Saitama Medical Center First Department of Integrated Medicine Division of Nephrology
 ( Watano Tatsuro ) - Jichi Medical University Saitama Medical Center Department of Laboratory Medicine
 ( Fujino Shinji ) - Jichi Medical University Saitama Medical Center Department of Laboratory Medicine
 ( Omoto Kiyoka ) - Jichi Medical University Saitama Medical Center Department of Laboratory Medicine
 ( Morishita Yoshiyuki ) - Jichi Medical University Saitama Medical Center First Department of Integrated Medicine Division of Nephrology

Abstract


Background: Few studies have investigated the relationship between serum total carbon dioxide (CO2) concentration and bicarbonate ion (HCO3-) concentration in patients undergoing hemodialysis. We determined the agreement and discrepancy between serum total CO2 and HCO3- concentrations and the diagnostic accuracy of serum total CO2 for the prediction of low (HCO3- < 24 mEq/L) and high (HCO3- ≥ 24 mEq/L) bicarbonate concentrations in hemodialysis patients.

Methods: One hundred forty-nine arteriovenous blood samples from 84 hemodialysis patients were studied. Multiple linear regression analysis was used to determine factors correlated with HCO3- concentration. Diagnostic accuracy of serum total CO2 was evaluated using receiver operating characteristic curve analysis and a 2 × 2 table. Agreement between serum total CO2 and HCO3- concentrations was assessed using Bland-Altman analysis.

Results: Serum total CO2 concentration was closely correlated with HCO3- concentration (β = 0.858, P < 0.001). Area under the curve of serum total CO2 for the identification of low and high bicarbonate concentrations was 0.989. Use of serum total CO2 to predict low and high bicarbonate concentrations had a sensitivity of 100%, specificity of 50.0%, positive predictive value of 96.5%, negative predictive value of 100%, and accuracy of 96.6%. Bland-Altman analysis showed moderate agreement between serum total CO2 and HCO3- concentrations. Discrepancies between HCO3- and serum total CO2 concentrations (serum total CO2 - HCO3- ≤ -1) were observed in 89 samples.

Conclusion: Serum total CO2 concentration is closely correlated with HCO3- concentration in hemodialysis patients. However, there is a non-negligible discrepancy between serum total CO2 and HCO3- concentrations.

키워드

Acid base balance; Bicarbonate; Hemodialysis; Serum total carbon dioxide

원문 및 링크아웃 정보

등재저널 정보