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Regional Quantitative Magnetic Resonance Imaging Data Improve Screening Accuracy of Subjective Memory Complaints and Informant Reports of Cognitive Decline

Psychiatry Investigation 2020년 17권 9호 p.851 ~ 857
임선진, 이다현, 변민수, 성기영, 이동영,
소속 상세정보
임선진 ( Yim Seon-Jin ) - National Center for Mental Health Department of Geriatric Psychiatry
이다현 ( Yi Da-Hyun ) - Seoul National University Medical Research Center Institute of Human Behavioral Medicine
변민수 ( Byun Min-Soo ) - Seoul National University Medical Research Center Institute of Human Behavioral Medicine
성기영 ( Sung Ki-Young ) - Seoul National University Hospital Department of Neuropsychiatry
이동영 ( Lee Dong-Young ) - Seoul National University Hospital Department of Neuropsychiatry

Abstract


Objective: We investigated whether the addition of Alzheimer’s disease-signature region cortical thickness (AD-Ct) and hippocampal volume (Hv) obtained from brain MRI to subjective memory complaints and informant-reports of cognitive decline enhances the screening accuracy for cognitive disorders in a memory clinic setting.

Methods: 120 participants (40 cognitively normal, 40 MCI, 40 dementia) underwent clinical evaluation, neuropsychological assessment, and brain MRI. The Subjective Memory Complaints Questionnaire (SMCQ) and Seoul Informant-Report Questionnaire for Dementia (SIRQD) were applied to assess subjective memory complaints and informant-reports of cognitive decline respectively. Logistic regression and ROC curve analyses were conducted to compare the screening abilities of SMCQ+SIRQD, SMCQ+SIRQD+Hv, and SMCQ+SIRQD+AD-Ct models for cognitive disorders.

Results: SMCQ+SIRQD+Hv model indicated better screening accuracy for MCI and overall cognitive disorder (CDall) than SMCQ+ SIRQD model. SMCQ+SIRQD+AD-Ct model had superior screening accuracy for dementia in comparison to SMCQ+SIRQD model. ROC curve analyses revealed that SMCQ+SIRQD+Hv model had the greatest area under the curve (AUC) for screening MCI and CDall (AUC: 0.941 and 0.957), while SMCQ+SIRQD+AD-Ct model had the greatest AUC for screening dementia (AUC: 0.966).

Conclusion: Our results suggest that the addition of regional quantitative MRI data enhances the screening ability of subjective memory complaints and informant-reports of cognitive decline for MCI and dementia.

키워드

Cognitive disorder; Screening; Subjective memory complaint; Informant report; MRI

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