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Depression and APOEε4 Status in Individuals with Subjective Cognitive Decline: A Meta-Analysis

Psychiatry Investigation 2020년 17권 9호 p.858 ~ 864
Huang Yue-Ping, Xue Ju-Jun, Li Chao, Chen Xi, Fu Hong-Juan, Fei Teng, Bi Peng-Xiang,
소속 상세정보
 ( Huang Yue-Ping ) - Heilongjiang Provincial Hospital Department of Gerontological Neurology
 ( Xue Ju-Jun ) - Heilongjiang Provincial Hospital Department of Gerontological Neurology
 ( Li Chao ) - Mudanjiang Medical College Hongqi Hospital Department of Neurology
 ( Chen Xi ) - Heilongjiang Provincial Hospital Department of Experimental Diagnosis
 ( Fu Hong-Juan ) - Heilongjiang Provincial Hospital Department of Gerontological Neurology
 ( Fei Teng ) - Heilongjiang Provincial Hospital Department of Experimental Diagnosis
 ( Bi Peng-Xiang ) - Mudanjiang Medical College Hongqi Hospital Department of Neurology

Abstract


Objective: To evaluate the associative role of depression and apolipoprotein E epsilon 4 allele (APOEε4) in subjective cognitive decline (SCD) and its progression to objective cognitive decline.

Methods: After literature search in electronic databases, studies were selected by following precise eligibility criteria. Meta-analyses were performed to examine the role of APOEε4 and depression in SCD or its progression to mild cognitive impairment (MCI) or dementia.

Results: APOEε4 positivity was not different between SCD and normal individuals but was significantly higher in individuals with SCD plus than in normal individuals [odds ratio: 2.39 (95% CI: 1.87, 3.05); p<0.00001] and in SCD converters than in non-converters [odds ratio: 5.19 (95% CI: 2.36, 11.42); p<0.00001]. Depression was significantly higher in individuals with SCD [standardized mean difference: 0.63 (0.45, 0.82); p<0.00001] and SCD plus [standardized mean difference: 0.83 (0.43, 1.22); p<0.0001] than in normal individuals. However, depression was not different between SCD and MCI or between SCD converters and non-converters. Age of SCD converters was higher than non-converters [mean difference: 2.95 years (0.58, 5.31)].

Conclusion: Whereas APOEε4 positivity was higher in SCD plus and SCD converters, depression was higher in SCD and SCD plus but was not different between SCD and MCI.

키워드

Subjective cognitive decline; Apolipoprotein E4; Depression; Dementia risk

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