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Brain Network Connectivity and Association with Catechol-O-Methyltransferase Gene Polymorphism in Korean Attention-Deficit Hyperactivity Disorder Children

Psychiatry Investigation 2020년 17권 9호 p.925 ~ 933
박정하, 손영돈, 김예니, 한덕현,
소속 상세정보
박정하 ( Park Jeong-Ha ) - Woorisoa Children’s Hospital Department of Psychiatry
손영돈 ( Son Young-Don ) - Gachon University Department of Health Sciences and Technology
김예니 ( Kim Ye-Ni ) - National Center for Mental Health Department of Child and Adolescent Psychiatry
한덕현 ( Han Doug-Hyun ) - Chung-Ang University Hospital Department of Psychiatry

Abstract


Objective: We sought to determine if the links between and within the default mode network (DMN) and dorsal attention network (DAT) exhibited different conditions according to catechol-O-methyltransferase (COMT) gene polymorphism in relationship to attention-deficit hyperactivity disorder (ADHD) symptoms.

Methods: Fifty-seven children with ADHD and 48 healthy controls (HCs) were administered an intelligence test, the Children’s Depression Inventory, the Korean ADHD rating scale, and continuous performance test. Resting-state brain functional MRI scans were obtained, and COMT genotyping was performed to distinguish valine carriers and methionine homozygotes.

Results: Compared to controls, children with ADHD showed increased ADHD scale scores, increased visual commission errors, and increased functional connectivity (FC) within the DMN and DAT. Compared to all children with ADHD, children with the methionine homozygote and those who were valine carriers showed increased FC within the DMN and DAT and decreased FC between the DMN and DAT. FC within the DMN was also increased in HC valine carriers compared to HC children with the methionine homozygote, and in children with ADHD who were valine carriers compared to HC valine carriers.

Conclusion: We observed increased brain connectivity within the DMN and DAT and altered brain connectivity within and between the DMN and DAT associated with COMT polymorphism in children with ADHD.

키워드

Attention-deficit hyperactivity disorder; Dorsal attention network; Default mode network; Catechol-O-methyltransferase

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