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Positive Association of Human SHC3 Gene with Schizophrenia in a Northeast Chinese Han Population

Psychiatry Investigation 2020년 17권 9호 p.934 ~ 940
Lv Ye, Sun Yang, Wang Guan-Yu, Yin Jian, Li Cheng-Jie, Luo Yi-Yang, Luan Zhi-Lin,
소속 상세정보
 ( Lv Ye ) - Dalian Medical University Advanced Institute for Medical Sciences
 ( Sun Yang ) - Dalian Seventh People’s Hospital Department of Psychiatry
 ( Wang Guan-Yu ) - Dalian Medical University Second Affiliated Hospital Department of Neurosurgery
 ( Yin Jian ) - Dalian Medical University Second Affiliated Hospital Department of Neurosurgery
 ( Li Cheng-Jie ) - Dalian Medical University Advanced Institute for Medical Sciences
 ( Luo Yi-Yang ) - Dalian Medical University Advanced Institute for Medical Sciences
 ( Luan Zhi-Lin ) - Dalian Medical University Advanced Institute for Medical Sciences

Abstract


Objective: Schizophrenia is one of the most devastating neuropsychiatric disorders. Genetic epidemiological studies have confirmed that schizophrenia is a genetic disease. Genes promoting neurodevelopment may be potential candidates for schizophrenia. As an adaptor linking a number of tyrosine kinase receptors in multiple intracellular signaling cascades, Src homology 2 domain containing transforming protein 3 (SHC3) is a member of the Shc-like adaptor protein family, and expressed predominantly in the mature neurons of the central nervous system (CNS). In the present study, we aimed to investigate the association of SHC3 and schizophrenia.

Methods: An independent case-control association study was performed in a sample including 710 schizophrenia patients and 1314 healthy controls from a Northeast Chinese Han population.

Results: The allelic and genotypic association analyses showed that four SNPs in SHC3 significantly associated with schizophrenia (rs2316280, rs4877041, rs944485 and rs7021743). The haplotype composing of these four SNPs also showed significantly individual and global association with schizophrenia.

Conclusion: Our present results suggest SHC3 as a susceptibility gene for schizophrenia.

키워드

Schizophrenia; Association; Single nucleotide polymorphism (SNP); SHC3; Neurodevelopment

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