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Incongruent Expression of Brain-Derived Neurotrophic Factor and Cortisol in Schizophrenia: Results from a Randomized Controlled Trial of Laughter Intervention

Psychiatry Investigation 2020년 17권 12호 p.1191 ~ 1199
Cheng Shu-Li, Yang Fu-Chi, Chu Hsuan-Te, Tsai Chia-Kuang, Ku Shih-Chieh, Tseng Yu-Ting, Yeh Ta-Chuan, Liang Chih-Sung,
소속 상세정보
 ( Cheng Shu-Li ) - Mackay Medical College Department of Nursing
 ( Yang Fu-Chi ) - National Defense Medical Center Tri-Service General Hospital Department of Neurology
 ( Chu Hsuan-Te ) - National Defense Medical Center Tri-Service General Hospital Department of Psychiatry
 ( Tsai Chia-Kuang ) - National Defense Medical Center Tri-Service General Hospital Department of Neurology
 ( Ku Shih-Chieh ) - National Defense Medical Center Tri-Service General Hospital Department of Psychiatry
 ( Tseng Yu-Ting ) - National Defense Medical Center Tri-Service General Hospital Department of Psychiatry
 ( Yeh Ta-Chuan ) - National Defense Medical Center Tri-Service General Hospital Department of Psychiatry
 ( Liang Chih-Sung ) - National Defense Medical Center Tri-Service General Hospital Department of Psychiatry

Abstract


Objective: Schizophrenia has been associated with dysfunction of the hypothalamic-pituitary-adrenal axis. Furthermore, alterations in neurotrophic factors might contribute to the pathogenesis of schizophrenia. We aimed to evaluate the effects of a simulated laughter intervention on the levels of cortisol and BDNF and to determine whether the effects associated with simulated laughter could be sustained after discontinuation of the intervention.

Methods: In this randomized controlled study, patients with schizophrenia according to DSM-IV clinical criteria were randomly assigned to receive either 8-week-long simulated laughter intervention (n=32) or treatment-as-usual group (control group, n=27). The serum levels of BDNF and cortisol were measured at baseline, week 8, and four weeks after discontinuation (week 12) of the intervention program.

Results: After an 8-week simulated laughter intervention, the laughter group had significantly higher levels of BDNF; however, four weeks after discontinuation of the intervention, the levels of BDNF significantly dropped. Interestingly, the levels of cortisol did not change significantly at week 8, but they were significantly elevated at week 12. The levels of BDNF and cortisol in the control group did not change significantly between week 0 and week 8.

Conclusion: These findings suggest that the simulated laughter intervention has an early effect on neurogenesis with a significant delayed effect on stress regulation in subjects with schizophrenia.

키워드

Laughter therapy; Brain-derived neurotrophic factor; Cortisol; Schizophrenia; Complementary therapies

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