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The Mediating Effect of Psychological Distress on the Association between BDNF, 5-HTTLPR, and Tinnitus Severity

Psychiatry Investigation 2021년 18권 3호 p.187 ~ 195
정조은, 전세계, 한재상, 조은영, 홍경수, 박시내, 김정진,
소속 상세정보
정조은 ( Jeong Jo-Eun ) - Catholic University College of Medicine Daejeon St. Mary’s Hospital Department of Psychiatry
전세계 ( Jeon Se-Kye ) - Catholic University College of Medicine Department of Psychiatry
한재상 ( Han Jae-Sang ) - Catholic University College of Medicine Seoul St. Mary′s Hospital Department of Otorhinolaryngology-Head and Neck Surgery
조은영 ( Cho Eun-Young ) - Samsung Biomedical Research Institute Center of Clinical Research
홍경수 ( Hong Kyung-Sue ) - Sungkyunkwan University School of Medicine Samsung Seoul Hospital Department of Psychiatry
박시내 ( Park Shi-Nae ) - Catholic University College of Medicine Seoul St. Mary′s Hospital Department of Otorhinolaryngology-Head and Neck Surgery
김정진 ( Kim Jung-Jin ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Psychiatry

Abstract


Objective: To investigate the association between genetic polymorphisms of brain-derived neurotrophic factor (BDNF) or serotonin transporter gene-linked polymorphic region (5-HTTLPR) and tinnitus, and the mediating effects of psychological distress on this association.

Methods: Eighty-six patients experiencing tinnitus and 252 controls were recruited. The Tinnitus Handicap Inventory was used to assess the severity of tinnitus and the Beck Depression Inventory-II (BDI-II), Beck Anxiety Inventory-II (BAI-II), and the Korean version of the Brief Encounter Psychosocial Instrument (BEPSI-K) were used to assess psychological distress. We compared the association of BDNF rs6265 (Val66Met) and 5-HTTLPR variants in the two groups. The mediating effects of BDI-II, BAI-II, and BEPSI-K were examined using multiple regression analysis and validated by the Sobel test and bootstrapping.

Results: No significant differences were found between the groups regarding BDNF Val66Met and 5-HTTLPR, but the 5-HTTLPR variants trended toward association. Depressive symptoms appeared to act as a mediator on the relationship within the 5-HTTLPR s/s genotype and the severity of tinnitus.

Conclusion: Our findings provide a speculative idea on the association between the serotonergic system and tinnitus and suggest that depressive symptoms act as a mediator in tinnitus. Therefore, screening for depressive symptoms in patients with tinnitus is essential and intervention for depressive symptoms may help alleviate the severity of tinnitus.

키워드

Tinnitus; Brain-derived neurotrophic factor; Serotonin plasma membrane transporter proteins; Genetic association studies; Depression

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