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The Interaction of Inflammatory Markers and Alcohol-Use on Cognitive Function in Korean Male Firefighters

Psychiatry Investigation 2021년 18권 3호 p.205 ~ 213
윤지애, 정경숙, 안연순, 한유리, 최경숙,
소속 상세정보
윤지애 ( Yun Ji-Ae ) - Eulji University Hospital Department of Neuropsychiatry
정경숙 ( Jeong Kyoung-Sook ) - Yonsei University Wonju College of Medicine Department of Preventive Medicine
안연순 ( Ahn Yeon-Soon ) - Yonsei University Wonju College of Medicine Department of Preventive Medicine
한유리 ( Han Yu-Ri ) - Yonsei University Wonju College of Medicine
최경숙 ( Choi Kyeong-Sook ) - Eulji University Hospital Department of Neuropsychiatry

Abstract


Objective: Cognitive functions have been shown to become impaired due to alcoholism. Recently, neuroinflammation gained attention for playing a role in the neurotoxic effect of alcohol. However, there is limited data on the relationship between alcohol and cognitive function, based on the mechanism of inflammation. This study examined whether the interaction between alcohol use and pro-inflammatory biomarkers is related to cognitive function in Korean male firefighters.

Methods: A total of 474 firefighters were assessed for alcohol-related problems using CAGE, cognitive functions, and pro-inflammatory biomarkers (CRP, IL-6, TNF-α). Sequential multiple regression analyses were conducted to determine if inflammatory markers moderate the relationship between alcohol use and cognitive function.

Results: Only a decreased attentional function was associated with the interaction of alcohol use and inflammatory markers, after controlling for age, sex, body mass index, lipid profiles, smoking, depression, fatigue, self-reported hypertension, diabetes, and musculoskeletal problems.

Conclusion: This study revealed that the interaction between alcohol use and inflammation is related to attentional function in Korean male firefighters. Additionally, this cross-sectional study suggests that diminishing attention, related to alcohol use, may be based on the mechanism of inflammation.

키워드

Alcohol dependence; Attention; Cognitive decline; Firefighter; Inflammatory marker

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