잠시만 기다려 주세요. 로딩중입니다.

항암화학요법 유발 말초신경병증에 대한 봉독 약침 요법의 효과 및 기전에 대한 실험연구 고찰

Review of Experimental Researches on Bee Venom Pharmacopuncture Therapy for Chemotherapy-induced Peripheral Neuropathy

동의생리병리학회지 2021년 35권 1호 p.1 ~ 7
권보인, 우연주, 김주희,
소속 상세정보
권보인 ( Kwon Bo-In ) - Sangji University College of Korean Medicine Department of Pathology
우연주 ( Woo Yeon-Ju ) - Sangji University College of Korean Medicine Department of Physiology
김주희 ( Kim Joo-Hee ) - Sangji University College of Korean Medicine Department of Acupuncture & Moxibustion Medicine

Abstract


Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common dose-limiting side effects of neurotoxic chemotherapeutic agents that lead to decreased quality of life and dose reduction, delay or even cessation of treatment. The purpose of this systematic review is to evaluate the effect and the underlying mechanisms of bee venom (BV) pharmacopuncture therapy for CIPN in animal models. We searched for the available experimental literature using BV for CIPN through the Pubmed databases. Ten experimental studies were finally included in this review. In the oxaliplatin or paclitaxel-induced CIPN animal model, BV significantly relieved pain caused both mechanical and cold stimulation. It was suggested that the effect of BV is mediated by the stimulation effect of spinal α1- and α2-adrenergic receptors as a potential mechanism. In the future, more experimental studies are needed.

키워드

Chemotherapy-induced peripheral neuropathy; Bee venom; Pharmacopuncture; Experimental research; Review

원문 및 링크아웃 정보

 

등재저널 정보