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MPP+로 유도된 신경 독성에 대한 녹각의 보호 효과

Neuroprotective Effects of Cervi Cornu in MPP+ Treated SH-SY5Y Cells

경락경혈학회지 2020년 37권 2호 p.97 ~ 103
여수정,
소속 상세정보
여수정 ( Yeo Su-Jung ) - Sangji University College of Korean Medicine Department of Meridian & Acupoints

Abstract


Objectives: : Parkinson’s disease, a progressive neurodegenerative disease, is caused by the loss of dopaminergic neurons in the substantia nigra. There is no clear treatment or remedy for Parkinson’s disease; therefore, the development of novel therapies related to anti-inflammatory and antioxidant effects is required. This study was performed to evaluate the neuroprotective effect of water extracts from Cervi Cornu (CC) in dopaminergic cells.

Methods : We studied effects of CC on apoptosis, cell death and inflammation in SH?SY5Y neuroblastoma cells treated by methylpyridinium ion (MPP+). SH-SY5Y cell line was treated with CC for 24 hours and then 500 μM MPP+ for 18 hours.

Results : Cervi Cornu treatment inhibited the decrease in tyrosine hydroxylase (TH) expression and decreased the activation of inflammatory factors mitochondrial cytochrome C oxidase (COX2) and inducible NO synthase (iNOS) against MPP+ neurotoxicity. Apoptosis factors BCL2 associated X, apoptosis regulator (BAX) levels were decreased and B-Cell CLL/Lymphoma 2 (BCL2) levels were increased.

Conclusions : These results suggest that CC treatment had neuroprotective effects in the SH?SY5Y neuroblastoma cells against toxicity induced by MPP+. The results suggest new possibilities of CC for the treatment of Parkinson’s disease.

키워드

Cervi Cornu; Parkinson’s disease; neuroprotection; MPP+; SH?SY5Y

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