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대방풍탕의 흰 쥐 비복근 불용성 근위축에 대한 억제 효과

The Suppressive Effects of Daebangfung-tang against Disuse Muscle Atrophy in Gastrocnemius of Rats

경락경혈학회지 2020년 37권 4호 p.262 ~ 270
김재훈, 이정희, 이정희, 이초인, 이봉효, 이윤규, 이현종, 김재수,
소속 상세정보
김재훈 ( Kim Jae-Hoon ) - Daegu Haany University College of Korean Medicine Department of Acupuncture & Moxibustion Medicine
이정희 ( Lee Jung-Hee ) - Daegu Haany University College of Korean Medicine Department of Acupuncture & Moxibustion Medicine
이정희 ( Lee Jung-Hee ) - Daegu Haany University College of Korean Medicine Department of Acupuncture & Moxibustion Medicine
이초인 ( Lee Cho-In ) - Daegu Haany University College of Korean Medicine Department of Acupuncture & Moxibustion Medicine
이봉효 ( Lee Bong-Hyo ) - Daegu Haany University College of Korean Medicine Department of Acupuncture & Moxibustion Medicine
이윤규 ( Lee Yun-Kyu ) - Daegu Haany University College of Korean Medicine Department of Acupuncture & Moxibustion Medicine
이현종 ( Lee Hyun-Jong ) - Daegu Haany University College of Korean Medicine Department of Acupuncture & Moxibustion Medicine
김재수 ( Kim Jae-Soo ) - Daegu Haany University College of Korean Medicine Department of Acupuncture & Moxibustion Medicine

Abstract


Objectives : The aim of this study is to evaluate the effect of Daebangfung-tang (DBFT) on suppressing muscle atrophy followed by immobilization.

Methods : Twenty young male Sprague-Dawley rats were randomized into two groups. The rats in experimental group (DBFT group) were orally administrated DBFT once a day for 2 weeks, and the rats in control group were given normal saline in the same manner. The immobilization on left leg was carried out using casting tape. The morphologies of gastrocnemius in both groups were assessed. The cross sectional area of them was measured by image analyzer. Immunohistochemical staining was implemented and the numbers of immunopositive cells implying the expression of TNF-α were measured and quantified.

Results : DBFT represented the significant suppressive effects against the weight loss of the left gastrocnemius muscle and the reduction in cross sectional area of the left gastrocnemius muscle compared with normal saline. Also the treatment with DBFT significantly reduced the expression of TNF-α in gastrocnemius compared with normal saline.

Conclusions : DBFT is thought to have the significant suppressive effect against muscle atrophy followed by immobilization.

키워드

disuse muscle atrophy; Daebangfung-tang; gastrocnemius; TNF-α

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