잠시만 기다려 주세요. 로딩중입니다.

Comprehensive Visual Rating Scale on Magnetic Resonance Imaging: Application to Prodromal Alzheimer Disease

Annals of Geriatric Medicine and Research 2021년 25권 1호 p.39 ~ 44
정재경, 장재원,
소속 상세정보
정재경 ( Chung Jae-Kyung ) - Kangwon National University Hospital Department of Neurology
장재원 ( Jang Jae-Won ) - Kangwon National University Hospital Department of Neurology

Abstract


Background: A comprehensive visual rating scale (CVRS) using brain magnetic resonance imaging (MRI) was previously developed to evaluate structural changes in the brains of older patients. This study investigated the usefulness of the CVRS in predicting dementia with Alzheimer disease (AD) in patients with prodromal AD.

Methods: We included 189 patients with prodromal AD with available data from the Alzheimer’s Disease Neuroimaging Initiative study. We evaluated all patients using CVRS and assessed their progression to AD dementia over 3 years of longitudinal follow-up. Survival analysis was performed using the Cox proportional hazards model to analyze the hazard ratios of the CVRS for progression to AD dementia.

Results: Among 189 patients with prodromal AD, 61 (32.3%) progressed to dementia. The mean baseline CVRS scores differed significantly between the stable and progressive groups (9.9±5.1 vs. 12.4±4.9; p=0.002). An initial high CVRS score was an independent risk factor for the progression to AD dementia (hazard ratio=1.110; 95% confidence interval, 1.043?1.182).

Conclusion: The baseline CVRS score predicted the progression to dementia in patients with prodromal AD, indicating its independent association with longitudinal cognitive decline.

키워드

Magnetic resonance imaging; Alzheimer disease; Cognitive dysfunction

원문 및 링크아웃 정보

등재저널 정보