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Evaluation of Reproducibility of Brain Volumetry between Commercial Software, Inbrain and Established Research Purpose Method, FreeSurfer

Journal of Clinical Neurology 2021년 17권 2호 p.307 ~ 316
이정빈, 이지영, 오세원, 정미선, 박지은, 문연실, 전홍준, 문원진,
소속 상세정보
이정빈 ( Lee Jung-Bin ) - Soonchunhyang University Bucheon Hospital Department of Radiology
이지영 ( Lee Ji-Young ) - Hanyang University Medical Center Department of Radiology
오세원 ( Oh Se-Won ) - Soonchunhyang University Cheonan Hospital Department of Radiology
정미선 ( Chung Mi-Sun ) - Chung-Ang University Hospital Department of Radiology
박지은 ( Park Ji-Eun ) - University of Ulsan College of Medicine Asan Medical Center Department of Radiology
문연실 ( Moon Yeon-Sil ) - Konkuk University School of Medicine Konkuk University Medical Center Department of Neurology
전홍준 ( Jeon Hong-Jun ) - Konkuk University School of Medicine Konkuk University Medical Center Department of Psychiatry
문원진 ( Moon Won-Jin ) - Konkuk University School of Medicine Konkuk University Medical Center Department of Radiology

Abstract


Background and Purpose: We aimed to determine the intermethod reproducibility between the commercial software Inbrain (MIDAS IT) and the established research-purpose method FreeSurfer, as well as the effect of MRI resolution and the pathological condition of subjects on their intermethod reproducibility.

Methods: This study included 45 healthy volunteers and 85 patients with mild cognitive impairment (MCI). In 43 of the 85 patients with MCI, three-dimensional, T1-weighted MRI data were obtained at an in-plane resolution of 1.2 mm. The data of the remaining 42 patients with MCI and the healthy volunteers were obtained at an in-plane resolution of 1.0 mm. The within-subject coefficient of variation (CoV), intraclass correlation coefficient (ICC), and effect size were calculated, and means were compared using paired t-tests. The parameters obtained at 1.0-mm and 1.2-mm resolutions in patients with MCI were compared to evaluate the effect of the in-plane resolution on the intermethod reproducibility. The parameters obtained at a 1.0-mm in-plane resolution in patients with MCI and healthy volunteers were used to analyze the effect of subject condition on intermethod reproducibility.

Results: Overall the two methods showed excellent reproducibility across all regions of the brain (CoV=0.5?3.9, ICC=0.93 to >0.99). In the subgroup of healthy volunteers, the intermethod reliability was only good in some regions (frontal, temporal, cingulate, and insular). The intermethod reproducibility was better in the 1.0-mm group than the 1.2-mm group in all regions other than the nucleus accumbens.

Conclusions: Inbrain and FreeSurfer showed good-to-excellent intermethod reproducibility for volumetric measurements. Nevertheless, some noticeable differences were found based on subject condition, image resolution, and brain region.

키워드

magnetic resonance imaging; reproducibility of results; mild cognitive impairment; brain, volumetry

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