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Campbell Early 잎 추출물이 Isoprenaline 유발 심근병증 랫트에서 심장-신장 개선에 미치는 영향

Effect of Campbell Early Leaves Extract on Heart-Kidney Improvement Cardiomyopathy in Isoprenaline-Induced Rats

한국식품영양과학회지 2021년 50권 3호 p.211 ~ 218
홍미현, 김혜윰,
소속 상세정보
홍미현 ( Hong Mi-Hyeon ) - Wonkwang University College of Oriental Medicine Department of Physiology
김혜윰 ( Kim Hye-Yoom ) - Wonkwang University College of Oriental Medicine Department of Physiology

Abstract

결론적으로, ISO 주입으로 심근병증을 유발하여 심장과 신장의 구조 변화 및 기능 손상(심신증후군)을 일으켰으며, Campbell early 잎이 이를 개선시키는 것으로 확인했다. 비록 용량 의존적인 효과를 보이진 않았지만 대체로 고농도의 Campbell early 잎 추출물이 더욱 심장 및 신장의 기능 이상을 개선하는 효과가 있다는 것을 알 수 있었다. 따라서 추후 심장-신장 상호 기전에 대한 후속 연구에 유용한 결과로 사용될 수 있을 것으로 보이며, 포도는 열매뿐만 아니라 잎 또한 심혈관계 질환 개선 소재로 활용이 가능할 것이라 사료된다.

Many studies have shown that grapes have antioxidant, nerve protection, liver protection, and anti-cancer effects, but their effectiveness on leaves is not known. The study was conducted to identify the effectiveness of Campbell early leaves (CEL) in heart and kidney dysfunction. Cardiomyopathy was induced by a treatment with isoprenaline (ISO) in rats to confirm the improved effect of cardiac-kidney dysfunction (cardio-renal syndrome). ISO (10 mg/kg/d) was administered intraperitoneally for two weeks and was divided into five groups: CONT, control; ISO, isoprenaline 10 mg/kg/d; PRO, ISO+propranolol 10 mg/kg; CEL100, ISO+CEL 100 mg/kg/d; CEL200, ISO+CEL 200 mg/kg/d. The experiment was conducted for four weeks. As a result, the CEL groups showed an improvement in the value of the left ventricle mass index after exposure to ISO compared to the control group. Furthermore, the echocardiogram measurements showed that the CEL groups could recover the decrease in ejection fraction, fractional shortening, and stroke volume. To identify the heart-kidney functionality, albumin, osmotic, and blood nitrogen was measured in each group, which showed a significant increase in the ISO group, decreasing in the CEL group. The fibrosis of the kidneys also recovered in the CEL group. In conclusion, in cardiomyopathy caused by ISO-induced rats, CEL improves the heart and kidney function. Therefore, grape leaves and fruit are considered useful for improving the heart-kidney functional disorders in grape leaves.

키워드

Campbell early leaves; cardiomyopathy; cardiorenal syndrome; heart-kidney dysfunction; functional food

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