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The impact of lymph node dissection on survival in patients with clinical early-stage ovarian cancer

Journal of Gynecologic Oncology 2021년 32권 3호 p.40 ~ 40
Deng Ting, Huang Qidan, Wan Ting, Luo Xiaoling, Feng Yanling, Huang He, Liu Jihong,
소속 상세정보
 ( Deng Ting ) - Sun Yat-sen University Cancer Center Department of Gynecologic Oncology
 ( Huang Qidan ) - Sun Yat-sen University Cancer Center Department of Gynecologic Oncology
 ( Wan Ting ) - Sun Yat-sen University Cancer Center Department of Gynecologic Oncology
 ( Luo Xiaoling ) - Sun Yat-sen University Cancer Center Department of Gynecologic Oncology
 ( Feng Yanling ) - Sun Yat-sen University Cancer Center Department of Gynecologic Oncology
 ( Huang He ) - Sun Yat-sen University Cancer Center Department of Gynecologic Oncology
 ( Liu Jihong ) - Sun Yat-sen University Cancer Center Department of Gynecologic Oncology

Abstract


Objective: To estimate the impact of lymph node dissection on survival in patients with apparent early-stage epithelial ovarian cancer (EOC).

Methods: We conducted a retrospective review of patients with clinical stage I?II EOC. All patients underwent primary surgery at Sun Yat-sen University Cancer Center between January 2003 and December 2015. Demographic features and clinicopathological information as well as perioperative adverse events were investigated, and survival analyses were performed.

Results: A total of 400 ovarian cancer patients were enrolled, and patients were divided into 2 groups: 81 patients did not undergo lymph node resection (group A), and 319 patients underwent lymph node dissection (group B). In group B, the median number of removed nodes per patient was 25 (21 pelvic and 4 para-aortic nodes). In groups A and B, respectively, the 5-year progression-free survival (PFS) rates were 83.3% and 82.1% (p=0.305), and the 5-year overall survival (OS) rates were 93.1% and 90.9% (p=0.645). The recurrence rate in the retroperitoneal lymph nodes was not associated with lymph node dissection (p=0.121). The median operating time was markedly longer in group B than in group A (220 minutes vs. 155 minutes, p<0.001), and group B had a significantly higher incidence of lymph cysts at discharge (32.9% vs. 0.0%, p<0.001).

Conclusion: In patients with early-stage ovarian cancer, lymph node dissection was not associated with a gain in OS or PFS and was associated with an increased incidence of perioperative adverse events.

키워드

Lymph Node Dissection; Ovarian Cancer; Survival

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