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Treadmill exercise in obese maternal rats during pregnancy improves spatial memory through activation of phosphatidylinositol 3-kinase pathway in the hippocampus of rat pups

Journal of Exercise Rehabilitation 2020년 16권 6호 p.483 ~ 488
고영준, 김보균, 지은상,
소속 상세정보
고영준 ( Ko Young-Jun ) - Kangnam University College of Welfare Convergence Major in Sport Service Practice
김보균 ( Kim Bo-Kyun ) - Gachon University College of Health Science Department of Emergency Technology
지은상 ( Ji Eun-Sang ) - Sangmyung University College of Art and Culture Department of Sport and Health Care

Abstract


Maternal nutrition is necessary for the growth of the fetus, and excessive intake of nutrients interferes with brain development in offspring. In the current study, the effect of treadmill running during pregnancy in obese maternal rats on spatial learning memory and spatial working memory in rat pups was investigated. Phosphorylation of phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt), and extracellular signal-regulated kinase 1 and 2 (ERK1/2) was also identified in rat pups. Female rats were divided into the normal diet group and the high-fat diet group for 7 weeks, including pregnancy and lactation. Maternal treadmill running was performed for 4 weeks. The born rat pups were classified into a control group, a treadmill exercise group, a high-fat diet group, a high-fat diet and treadmill exercise group according to the status of maternal rats. Radial 8-arm maze task for spatial learning memory and Morris water maze task for spatial working memory were done. Western blot analysis was conducted to determine the expressions of PI3K, Akt, ERK1/2. In the current results, maternal treadmill running during pregnancy improved spatial learning memory and spatial working memory in rat pups born to obese maternal rats. This improving effect of memory was due to the enhanced phosphorylation of PI3K, Akt, and ERK1/2 by treadmill running.

키워드

Maternal obesity; Pregnancy; Treadmill exercise; PI3K; Rat pups

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