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Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Journal of Cancer Prevention 2020년 25권 3호 p.136 ~ 151
Gomathinayagam Rohini, 하지희, Jayaraman Muralidharan, 송영상, Isidoro Ciro, Dhanasekaran Danny N.,
소속 상세정보
 ( Gomathinayagam Rohini ) - University of Oklahoma Health Sciences Center Department of Cell Biology
하지희 ( Ha Ji-Hee ) - University of Oklahoma Health Sciences Center Department of Cell Biology
 ( Jayaraman Muralidharan ) - University of Oklahoma Health Sciences Center Department of Cell Biology
송영상 ( Song Yong-Sang ) - Seoul National University College of Medicine Department of Obstetrics and Gynecology
 ( Isidoro Ciro ) - Universita del Piemonte Orientale Department of Health Sciences
 ( Dhanasekaran Danny N. ) - University of Oklahoma Health Sciences Center Peggy and Stephenson Cancer Center

Abstract


Thymoquinone (TQ) is a bioactive component derived from the seeds of Nigella sativa that are commonly as black cumin. Evidences indicate that the medicinal properties of TQ have been recognized for more than 2000 years. TQ has been shown to possess potent chemopreventive properties that include anti-inflammatory and anti-neoplastic activities. Recent studies have unraveled the multiple mechanisms through which TQ exerts its chemopreventive and anticancer activity in different cancer cells in a contextual manner. The present review aims to provide a brief compendium on the molecular mechanisms through which TQ inhibits signaling pathways underlying cancer genesis, progression, and metastasis.

키워드

Nigella sativa; Thymoquinone; Neoplasms; Chemoprevention; Antineoplastic agent

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