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Understanding the Mechanistic Link between Bisphenol A and Cancer Stem Cells: A Cancer Prevention Perspective

Journal of Cancer Prevention 2021년 26권 1호 p.18 ~ 24
Winz Cassandra, 서난주,
소속 상세정보
 ( Winz Cassandra ) - Ernest Mario School of Pharmacy Department of Chemical Biology
서난주 ( Suh Nan-Joo ) - Ernest Mario School of Pharmacy Department of Chemical Biology

Abstract


Endocrine disruptors, such as bisphenol A (BPA), have become more frequently present in the environment as contaminants, especially in industrialized countries. Long-term effects of these environmental contaminants in humans are elusive. With their structural similarity to estrogen, many environmental contaminants including BPA, have been shown to mimic the biological functions of estrogen, potentially contributing to the development of breast cancer. It has been well established that BPA exerts estrogenic activity in animal models and in vitro systems. There is a concern for adverse effects from the exposure to BPA in regard to developmental and reproductive toxicities. However, the mechanisms by which BPA promotes breast cancer development remain unknown. Understanding the role of endocrine disruptors and their key mechanisms of action is important for public health, especially by providing a foundation for a better intervention approach in cancer prevention.

키워드

Breast cancer; Cancer stem cells; Endocrine disruptors; Estrogen receptor

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