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Factors increasing the risk of mortality and morbidity due to coronavirus infection in patients with metabolic syndrome

Precision and Future Medicine 2020년 4권 3호 p.83 ~ 90
Enkhtur Altansuvd, 윤준섭, 이창우,
소속 상세정보
 ( Enkhtur Altansuvd ) - Sungkyunkwan University School of Medicine Department of Molecular Cell Biology
윤준섭 ( Yoon Joon-Sup ) - Sungkyunkwan University School of Medicine Department of Molecular Cell Biology
이창우 ( Lee Chang-Woo ) - Sungkyunkwan University School of Medicine Department of Molecular Cell Biology

Abstract


Patients living with comorbid metabolic syndrome (MS) and metabolic disorders such as obesity and type 2 diabetes mellitus carry increased levels of circulating cytokines and systemic low-grade inflammation. Upon viral infection, such patients with all pre-existing backgrounds, specifically dysregulated inflammatory signalling, leads to rapid viral replication and results in worse clinical outcomes. The increased pro-inflammatory cytokine release is a risk factor, and therefore, targeting inflammatory signalling pathways represents a potential therapeutic target to control the cytokine release, and thereby prevent serious outcomes, such as increased mortality and morbidity. In this review, we elucidate the factors underlying the increased morbidity and mortality in patients with MS and virus infection, particularly coronavirus.

키워드

COVID-19; Inflammation; JAK kinases; Metabolic syndrome; STAT transcription factors

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