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Infectious causes of acute ischemic stroke: pathomechanisms and distribution of brain infarct

Precision and Future Medicine 2020년 4권 3호 p.114 ~ 118
Li Wenyu, 김진희, Zhang Jinhua, 방오영,
소속 상세정보
 ( Li Wenyu ) - Zhejiang University Medical School Sir Run Run Shaw Hospital Department of Neurology
김진희 ( Kim Jin-Hee ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Neurology
 ( Zhang Jinhua ) - Zhejiang University Medical School Sir Run Run Shaw Hospital Department of Neurology
방오영 ( Bang Oh-Young ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Neurology

Abstract


Infectious diseases and stroke are common and a great health problem worldwide. However, relatively few studies have focused on direct infectious causes of acute stroke, and the exact mechanisms of acute stroke associated with infections are poorly understood. Herein, we present several infectious organisms that are probable causes of stroke. Different pathomechanisms of stroke and neuroimaging features of infection by these organisms are discussed. Specifically, the distribution of cerebral infarction suggests that infections could be a direct cause of acute stroke. These include cerebral convexity probably due to vasculitis in bacterial meningitis, deep infarcts due to endarteritis and inflammation in neurocysticercosis, and exudates in tuberculous meningitis, as well as hemodynamic borderzone infarct due to large vessel vasculitis by direct invasion of fungal infection. We suggest that prompt and appropriate control of these organisms could prevent ischemic stroke.

키워드

Cerebral infarction; Meningitis; Neuroimaging; Stroke; Vasculitis

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