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Cognitive Impairments and Associated Structural Brain Changes in Metabolic Syndrome and Implications of Neurocognitive Intervention

Journal of Obesity & Metabolic Syndrome 2020년 29권 3호 p.174 ~ 179
Kordestani-Moghadam Parastou, Assari Shervin, Nouriyengejeh Sarah, Mohammadipour Fatemeh, Pourabbasi Ata,
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 ( Kordestani-Moghadam Parastou ) - Lorestan University of Medical Sciences Social Determinants of Health Research Center
 ( Assari Shervin ) - University of Michigan Department of Psychiatry
 ( Nouriyengejeh Sarah ) - Tehran University of Medical Sciences Endocrinology and Metabolism Clinical Sciences Institute Endocrinology and Metabolism Research Center
 ( Mohammadipour Fatemeh ) - Lorestan University of Medical Sciences Student Research Committee
 ( Pourabbasi Ata ) - Tehran University of Medical Sciences Endocrinology and Metabolism Clinical Sciences Institute Endocrinology and Metabolism Research Center

Abstract


Currently, metabolic syndrome has become a global health problem. Alterations in neurocognitive functions among patients with metabolic syndrome are important issues in this disorder. In this paper, studies on metabolic syndrome were reviewed and their importance emphasized for the benefit of experts and policy makers. Metabolic syndrome activates inflammatory mediators that disrupt brain metabolism. These mediators can be activated by metabolic inflammation and microvascular disorders and may further cause damage to the white matter and impair cognitive function. These alterations can result in serious changes in cognitive abilities. The association between cognitive changes and metabolic syndrome has been independently evaluated in several studies. In addition, some areas of research in the field of metabolic syndrome include the effectiveness of neurocognitive interventions to enhance normal behaviors or reduce risky behaviors in patients. Structural brain correlates of health-related behaviors provide a basis for designing more effective behavioral interventions by identifying the corresponding brain regions and using behavioral interventions.

키워드

Brain structure; Metabolic syndrome; Neurocognitive intervention

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