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The Effects of Hydro-Alcoholic Extract of Fenugreek Seeds on the Lipid Profile and Oxidative Stress in Fructose-Fed Rats

Journal of Obesity & Metabolic Syndrome 2020년 29권 3호 p.198 ~ 207
Mohammad-Sadeghipour Maryam, Afsharinasab Mehdi, Mohamadi Maryam, Mahmoodi Mehdi, Falahati-pour Soudeh Khanamani, Hajizadeh Mohammad Reza,
소속 상세정보
 ( Mohammad-Sadeghipour Maryam ) - Kerman University of Medical Sciences Afzalipour School of Medicine Department of Clinical Biochemistry
 ( Afsharinasab Mehdi ) - Rafsanjan University of Medical Sciences Institute of Basic Medical Sciences Research Molecular Medicine Research Center
 ( Mohamadi Maryam ) - Rafsanjan University of Medical Sciences Institute of Basic Medical Sciences Research Molecular Medicine Research Center
 ( Mahmoodi Mehdi ) - Kerman University of Medical Sciences Afzalipour School of Medicine Department of Clinical Biochemistry
 ( Falahati-pour Soudeh Khanamani ) - Rafsanjan University of Medical Sciences Pistachio Safety Research Center
 ( Hajizadeh Mohammad Reza ) - Rafsanjan University of Medical Sciences Institute of Basic Medical Sciences Research Molecular Medicine Research Center

Abstract


Background: Metabolic syndrome (MetS) is a complex clinical disorder that can lead to an increase in oxidative stress. Patients with this syndrome are at risk of diabetes and cardiovascular disease. The Trigonella foenum-graecum L. (fenugreek) plant has many therapeutic effects, including anti-diabetic and antioxidant. The present study aimed to investigate the effects of the hydro-alcoholic extract of fenugreek seeds (HEFS) on dyslipidemia and oxidative stress due to high-fructose diet-induced MetS.

Methods: In this experimental study, to induce MetS, animals received water containing 20% fructose for 8 weeks. After induction of MetS, 48 male Wistar rats (200?250 g) were randomized into six groups. HEFS was administered to animals at doses of 100 and 200 mg/kg orally for 4 weeks. Animal blood samples were collected to measure biochemical and antioxidant parameters of fasting plasma glucose (FPG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), malondialdehyde (MDA), glutathione peroxidase (GPX), catalase (CAT), and total antioxidant capacity (TAC).

Results: The findings showed that the serum levels of FPG, TC, LDL-C, TG, and MDA were significantly reduced in HEFS-exposed groups compared with the control group (P<0.05). Also, significant increases in HDL-C, GPX, CAT, and TAC levels (P<0.05) were observed.

Conclusion: Our results revealed that treatment with HEFS increases the levels of antioxidant enzymes, decreases FPG level, and at the same time, modifies the lipid profile in MetS. Therefore, HEFS may help to alleviate the risk of some chronic complications of this disease.

키워드

Antioxidants; Dyslipidemia; Trigonella; Metabolic syndrome; Oxidative stress

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