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An In sight into Novel Drug Delivery System: In Situ Gels

TANG [HUMANITAS MEDICINE] 2021년 11권 1호 p.6 ~ 6
Bashir Rabiah, Maqbool Mudasir, Ara Irfat, Zehravi Mehrukh,
소속 상세정보
 ( Bashir Rabiah ) - University of Kashmir Department of Pharmaceutical Sciences
 ( Maqbool Mudasir ) - University of Kashmir Department of Pharmaceutical Sciences
 ( Ara Irfat ) - Regional Research Institute of Unani Medicine
 ( Zehravi Mehrukh ) - Prince Sattam Bin Abdul Aziz University Department of Clinical Pharmacy Girls Section

Abstract


In situ gelling devices, as they enter the body, are dosage forms in the shape of the sol but turn into gel types under physiological circumstances. Transition from sol to gel is contingent on one or a mixture of diverse stimuli, such as transition of pH control of temperature, irradiation by UV, by the occurrence of certain ions or molecules. Such characteristic features may be commonly employed in drug delivery systems for the production of bioactive molecules for continuous delivery vehicles. The technique of in situ gelling has been shown to be impactful in enhancing the potency of local or systemic drugs supplied by non-parenteral pathways, increasing their period of residence at the absorption site. Formulation efficacy is further improved with the use of mucoadhesive agents or the use of polymers with both in situ gelling properties and the ability to bind with the mucosa/mucus. The most popular and common approach in recent years has provided by the use of polymers with different in situ gelation mechanisms for synergistic action between polymers in the same formulation. In situ gelling medicine systems in recent decades have received considerable interest. Until administration, it is in a sol-zone and is able to form gels in response to various endogenous factors, for e.g elevated temperature, pH changes and ions. Such systems can be used in various ways for local or systemic supply of drugs and successfully also as vehicles for drug-induced nano- and micro-particles. In this review we will discuss about various aspects about use of these in situ gels as novel drug delivery systems.

키워드

Gels; in situ gelling system; polymers; pH change; stability

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