잠시만 기다려 주세요. 로딩중입니다.

Mechanisms of TERT Reactivation and Its Interaction with BRAFV600E

Endocrinology and Metabolism 2020년 35권 3호 p.515 ~ 525
송영신,
소속 상세정보
송영신 ( Song Young-Shin ) - CHA University School of Medicine CHA Bundang Medical Center Department of Internal Medicine

Abstract


The telomerase reverse transcriptase (TERT) gene, which is repressed in most differentiated human cells, can be reactivated by somatic TERT alterations and epigenetic modulations. Moreover, the recruitment, accessibility, and binding of transcription factors also affect the regulation of TERT expression. Reactivated TERT contributes to the development and progression of cancer through telomere lengthening-dependent and independent ways. In particular, because of recent advances in high-throughput sequencing technologies, studies on genomic alterations in various cancers that cause increased TERT transcriptional activity have been actively conducted. TERT reactivation has been reported to be associated with poor prognosis in several cancers, and TERT promoter mutations are among the most potent prognostic markers in thyroid cancer. In particular, when a TERT promoter mutation coexists with the BRAFV600E mutation, these mutations exert synergistic effects on a poor prognosis. Efforts have been made to uncover the mechanisms of these synergistic interactions. In this review, we discuss the role of TERT reactivation in tumorigenesis, the mechanisms of TERT reactivation across all human cancers and in thyroid cancer, and the mechanisms of interactions between BRAFV600E and TERT promoter mutations.

키워드

Telomerase; BRAF; Thyroid neoplasms; Genomics; Epigenomics

원문 및 링크아웃 정보

등재저널 정보

SCI(E)
MEDLINE
KCI
KoreaMed
KAMS