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Serum Transferrin Predicts New-Onset Type 2 Diabetes in Koreans: A 4-Year Retrospective Longitudinal Study

Endocrinology and Metabolism 2020년 35권 3호 p.610 ~ 617
김종대, 임동미, 박건영, 박세은, 이은정, 박철영, 이원영, 오기원,
소속 상세정보
김종대 ( Kim Jong-Dai ) - Konyang University College of Medicine Konyang University Hospital Department of Internal Medicine
임동미 ( Lim Dong-Mee ) - Konyang University College of Medicine Konyang University Hospital Department of Internal Medicine
박건영 ( Park Keun-Young ) - Konyang University College of Medicine Konyang University Hospital Department of Internal Medicine
박세은 ( Park Se-Eun ) - Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Internal Medicine
이은정 ( Rhee Eun-Jung ) - Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Internal Medicine
박철영 ( Park Cheol-Young ) - Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Internal Medicine
이원영 ( Lee Won-Young ) - Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Internal Medicine
오기원 ( Oh Ki-Won ) - Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Internal Medicine

Abstract


Background: It is well known that high serum ferritin, a marker of iron storage, predicts incident type 2 diabetes. Limited information is available on the association between transferrin, another marker of iron metabolism, and type 2 diabetes. Thus, we investigated the association between transferrin and incident type 2 diabetes.

Methods: Total 31,717 participants (mean age, 40.4±7.2 years) in a health screening program in 2005 were assessed via cross-sectional analysis. We included 30,699 subjects who underwent medical check-up in 2005 and 2009 and did not have type 2 diabetes at baseline in this retrospective longitudinal analysis.

Results: The serum transferrin level was higher in the type 2 diabetes group than in the non-type 2 diabetes group (58.32±7.74 μmol/L vs. 56.17±7.96 μmol/L, P<0.001). Transferrin correlated with fasting serum glucose and glycosylated hemoglobin in the correlational analysis (r=0.062, P<0.001 and r=0.077, P<0.001, respectively) after full adjustment for covariates. Transferrin was more closely related to homeostasis model assessment of insulin resistance than to homeostasis model assessment of β cell function (r=0.042, P<0.001 and r=?0.019, P=0.004, respectively) after full adjustment. Transferrin predicted incident type 2 diabetes in non-type 2 diabetic subjects in a multivariate linear regression analysis; the odds ratio (95% confidence interval [CI]) of the 3rd tertile compared to that in the 1st tertile of transferrin for incident diabetes was 1.319 (95% CI, 1.082 to 1.607) after full adjustment (P=0.006).

Conclusion: Transferrin is positively associated with incident type 2 diabetes in Koreans.

키워드

Transferrin; Diabetes mellitus, type 2; Insulin resistance

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