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Best Achievements in Translational and Basic Thyroidology in 2020

Endocrinology and Metabolism 2021년 36권 1호 p.36 ~ 40
조선욱, 박영주,
소속 상세정보
조선욱 ( Cho Sun-Wook ) - Seoul National University College of Medicine Seoul National University Hospital Department of Internal Medicine
박영주 ( Park Young-Joo ) - Seoul National University College of Medicine Seoul National University Hospital Department of Internal Medicine

Abstract


This review discusses articles published in 2020 that presented noteworthy achievements in translational and basic thyroidology. Previously unresolved questions about thyroid hormone receptor actions and signaling mechanisms were answered using various novel in vitro and in vivo models. Using high resolution cryo-electron microscopy, the fine functional structure of thyroglobulin was demonstrated, and new insights into the pathogenesis of thyroid disease were achieved, with a focus on research into thyroid-disrupting chemicals and the gut microbiome. Novel therapeutic approaches were tried in the field of advanced thyroid cancer treatments.

키워드

Receptors; thyroid hormone; Thyroglobulin; Gastrointestinal microbiome; Thyroid neoplasm; Endocrine disruptors

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