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Lung Organoids: Current Approaches and Future Promise

Obstructive Lung Disease 2021년 9권 1호 p.44 ~ 47
김정현, 홍석호,
소속 상세정보
김정현 ( Kim Jung-Hyun ) - Kangwon National University School of Medicine Department of Internal Medicine
홍석호 ( Hong Seok-Ho ) - Kangwon National University School of Medicine Department of Internal Medicine

Abstract


Numerous external stimulants including smoking, environmental pollution and virus lead to acute and chronic respiratory diseases, which are characterized by infiltration of immune cells, epithelial-to-mesenchymal transition, destruction of alveolar structure and reduction of lung function. Despite increased awareness of fatal respiratory diseases, molecular and physiological mechanisms of respiratory diseases remain to be elucidated due to lack of biologically relevant human in vitro lung model that recapitulate unique architecture and function of native lung tissue. In recent years, three-dimensional lung organoid derived from human lung tissues and pluripotent stem cells have great attention as an alternative source to recapitulate tissue architecture with high fidelity and served for various basic and preclinical studies. In this review, we will overview the current lung organoid technology for respiratory disease modeling, drug screening, virus research and future direction.

키워드

Organoid; Pluripotent stem cells; Lung; Disease modeling

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