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Differences Regarding the Molecular Features and Gut Microbiota Between Right and Left Colon Cancer

Annals of Coloproctology 2018년 34권 6호 p.280 ~ 285
김광민, Castro Ernes John T., 심홍진, Advincula John Vincent G., 김영완,
소속 상세정보
김광민 ( Kim Kwang-Min ) - Yonsei University Wonju College of Medicine Department of Surgery
 ( Castro Ernes John T. ) - Medical City Department of Surgery
심홍진 ( Shim Hong-Jin ) - Yonsei University Wonju College of Medicine Department of Surgery
 ( Advincula John Vincent G. ) - Amang Memorial Rodriguez Medical Center Department of Surgery
김영완 ( Kim Young-Wan ) - Yonsei University Wonju College of Medicine Department of Surgery

Abstract


For many years, developmental and physiological differences have been known to exist between anatomic segments of the colorectum. Because of different outcomes, prognoses, and clinical responses to chemotherapy, the distinction between right colon cancer (RCC) and left colon cancer (LCC) has gained attention. Furthermore, variations in the molecular features and gut microbiota between right and LCCs have recently been a hot research topic. CpG island methylator phenotype-high, microsatellite instability-high colorectal cancers are more likely to occur on the right side whereas tumors with chromosomal instability have been detected in approximately 75% of LCC patients and 30% of RCC patients. The mutation rates of oncogenes and tumor suppressor genes also differ between RCC and LCC patients. Biofilm is more abundant in RCC patients than LLC patients, as are Prevotella, Selenomonas, and Peptostreptococcus. Conversely, Fusobacterium, Escherichia/Shigella, and Leptotrichia are more abundant in LCC patients compared to RCC patients. Distinctive characteristics are apparent in terms of molecular features and gut microbiota between right and LCC. However, how or to what extent these differences influence diverging oncologic outcomes remains unclear. Further clinical and translational studies are needed to elucidate the causative relationship between primary tumor location and prognosis.

키워드

Colonic neoplasms; Molecular subtype; Gastrointestinal microbiome; Treatment outcome

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