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Female Sex and Right-Sided Tumor Location Are Poor Prognostic Factors for Patients With Stage III Colon Cancer After a Curative Resection

Annals of Coloproctology 2018년 34권 6호 p.286 ~ 291
박정호, 박형철, 박성찬, 오재환, 김덕우, 강성범, 허승철,
소속 상세정보
박정호 ( Park Jung-Ho ) - Hallym University Sacred Heart Hospital Department of Surgery
박형철 ( Park Hyoung-Chul ) - Hallym University Sacred Heart Hospital Department of Surgery
박성찬 ( Park Sung-Chan ) - National Cancer Center Center for Colorectal Cancer
오재환 ( Oh Jae-Hwan ) - National Cancer Center Center for Colorectal Cancer
김덕우 ( Kim Duck-Woo ) - Seoul National University Bundang Hospital Department of Surgery
강성범 ( Kang Sung-Bum ) - Seoul National University Bundang Hospital Department of Surgery
허승철 ( Heo Seung-Chul ) - Seoul Metropolitan Government-Seoul National University Boramae Medical Center Department of Surgery

Abstract


Purpose: Stage-IIIC colon cancer is an advanced disease; however, its oncologic outcomes and prognostic factors remain unclear. In this study, we aimed to determine the predictors of disease-free survival (DFS) in patients with stage-IIIC colon cancer.

Methods: From a multicenter database, we retrospectively enrolled 611 patients (355 men and 256 women) who had undergone a potentially curative resection for a stage-IIIC colon adenocarcinoma between 2003 and 2011. The primary end-point was the 5-year DFS.

Results: The median age was 62 years; 213 and 398 patients had right-sided colon cancer (RCC) and left-sided colon cancer (LCC), respectively. The 5-year DFS in all patients was 52.0%; median follow-up time was 35 months (range, 1?134 months). A multivariate Cox regression revealed that female sex (hazard ratio [HR], 1.50; 95% confidence interval [CI], 1.19?1.90; P < 0.01), right-sided tumor location (HR, 1.65; 95% CI, 1.29?2.11; P < 0.01), lymphatic invasion (HR, 1.52; 95% CI, 1.08?2.15; P < 0.01) and a high (≥0.4) metastatic lymph node ratio (HR, 3.72; 95% CI, 2.63?5.24; P < 0.01) were independent predictors of worse 5-year DFS. Female patients with RCC were 1.79 fold more likely to experience recurrence than male patients with LCC.

Conclusion: Female sex and right-sided tumor location are associated with higher tumor recurrence rates in patients with stage-IIIC colon cancers. Aggressive treatment and close surveillance should be planned for patients in these groups.

키워드

Colonic neoplasms; Ascending colon; Descending colon; Prognosis; Recurrence

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