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Risk Factors for Colorectal Cancer in Korea: A Population-Based Retrospective Cohort Study

Annals of Coloproctology 2019년 35권 6호 p.347 ~ 356
남수민, 최윤정, 김동욱, 박은철, 강중구,
소속 상세정보
남수민 ( Nam Soo-Min ) - National Health Insurance Service Ilsan Hospital Department of Surgery
최윤정 ( Choi Yoon-Jung ) - National Health Insurance Service Ilsan Hospital Department of Pathology
김동욱 ( Kim Dong-Wook ) - National Health Insurance Service Big Data Department
박은철 ( Park Eun-Cheol ) - Yonsei University College of Medicine Department of Preventive Medicine
강중구 ( Kang Jung-Gu ) - National Health Insurance Service Ilsan Hospital Department of Surgery

Abstract


Purpose: The incidence of colorectal cancer in Korea has recently increased, making it the second most common cancer in men and the third most common cancer in women. Risk factors for colorectal cancer have been studied worldwide, but risk factors specific for the Korean population have not been established. In this study, we investigated incidence trends and risk factors of colorectal cancer in Korea.

Methods: A total of 8,846,749 subjects were included. Colorectal cancer incidence was investigated using Korea National Health Insurance Service claim data from 2004 to 2014. Colorectal cancer diagnoses were obtained by evaluating colorectal cancer diagnostic codes and the cancer registry for cost sharing. Risk factor identification for colorectal cancer was obtained from National Health Examination data from 2004 to 2005. Cox proportional hazard model statistical analysis was used to determine risk factors of colorectal cancer.

Results: The incidence of colorectal cancer gradually increased from 2006 to 2014 (from 45.4/100,000 to 54.5/100,000). There was a predominance among men (1.47:1), but incidence trends were similar in both sexes. Old age, high body mass index, and no history of colonoscopy were identified as risk factors in both sexes. High fasting blood glucose, familial history of cancer, frequent alcohol intake, and current smoker were identified as risk factors, especially in men.

Conclusion: The incidence of colorectal cancer has been increasing in Korea. Colonoscopy screening was a protective factor for colorectal cancer, and active use of colonoscopy may reduce incidence. Early diagnosis and care are important, particularly for the high-risk group.

키워드

Colorectal neoplasms; Incidence; Risk factors; Population Characteristics

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