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FAS-670A>G gene polymorphism and the risk of allograft rejection after organ transplantation: a systematic review and meta-analysis

Blood Research 2021년 56권 1호 p.17 ~ 25
Eslami Mohammad Masoud, Rezaei Ramazan, Abdollahi Sara, Davari Afshin, Ahmadvand Mohammad,
소속 상세정보
 ( Eslami Mohammad Masoud ) - Tarbiat Modares University Faculty of Medical Sciences Department of Hematology
 ( Rezaei Ramazan ) - Shahid Beheshti University of Medical Sciences School of Medicine Department of Immunology
 ( Abdollahi Sara ) - Mazandaran University of Medical Sciences Mazandaran Faculty of Paramedical Sciences
 ( Davari Afshin ) - Tehran University of Medical Sciences School of Public Health Department of Medical Parasitology and Mycology
 ( Ahmadvand Mohammad ) - Tehran University of Medical Sciences Hematology-Oncology and Stem Cell Transplantation Research Center

Abstract


The association between the risk of allograft rejection after organ transplantation and FAS gene polymorphism has been evaluated previously. However, inconsistent results have been reported. Hence, we conducted the most up-to-date meta-analysis to evaluate this association. All eligible studies reporting the association between FAS-670A>G polymorphism and the risk of allograft rejection published up to December 2019 were extracted using a comprehensive systematic database search in the Web of Science, Scopus, and PubMed. The pooled odds ratios (OR) and corresponding 95% confidence intervals (CI) were calculated to determine the association strength. This meta-analysis included six case-control studies with 277 patients who experienced allograft rejection and 1,001 patients who did not experience allograft rejection (controls) after organ transplantation. The overall results showed no significant association between FAS-670A>G polymorphism and the risk of allograft rejection in five genetic models (dominant model: OR=0.81, 95% CI=0.58?1.12; recessive model: OR=0.10, 95% CI=0.80?1.53; allelic model: OR=0.96, 95% CI=0.79?1.18; GG vs. AA: OR=0.92, 95% CI=0.62?1.36; and AG vs. AA: OR=0.75, 95% CI=0.52?1.08). Moreover, subgroup analysis according to ethnicity and age did not reveal statistically significant results. Our findings suggest that FAS-670A>G polymorphism is not associated with the risk of allograft rejection after organ transplantation.

키워드

FAS; Allograft rejection; Polymorphism; Meta-analysis

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