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Risk Factors Associated with Recurrent Urinary Tract Infection Caused by Escherichia coli

Annals of Clinical Microbiology 2021년 24권 1호 p.11 ~ 20
김영아, 강이화, 서영희, 이경원,
소속 상세정보
김영아 ( Kim Young-Ah ) - National Health Insurance Service Ilsan Hospital Department of Laboratory Medicine
강이화 ( Kang Ea-Wha ) - National Health Insurance Service Ilsan Hospital Department of Internal Medicine
서영희 ( Seo Young-Hee ) - Yonsei University College of Medicine Research Institute of Bacterial Resistance
이경원 ( Lee Kyung-Won ) - Yonsei University College of Medicine Department of Laboratory Medicine

Abstract


Background: The purpose of this study was to analyze the clinical and microbiological characteristics of recurrent urinary tract infection (UTI) caused by Escherichia coli? the most common etiological agent.

Methods: Cases of recurrent and single episodes of UTI caused by E. coli were evaluated retrospectively for a period of 6 months (January-June 2019) to analyze the clinical and molecular characteristics of this disease.

Results: Healthcare-associated UTI, E. coli bacteremia, and poor microbial clearance 7 days post infection were associated more with the recurrent episodes of infection. E. coli isolates from subjects with recurrent UTIs showed higher rates of antimicrobial resistance and extended-spectrum β-lactamase (ESBL) production. The E. coli clone? sequence type 131 was detected in similar proportions in isolates, recovered from subjects in both groups? recurrent episodes and single episode of UTI.

Conclusion: The control of antimicrobial-resistant ESBL-producing E. coli strains may be difficult using antimicrobial therapy and subsequently delay the clearance of the etiologic agent. This could play a major role in the development of recurrent UTIs.

키워드

Escherichia coli; Extended-spectrum β-lactamases; Recurrent urinary tract infection; Risk factors; Sequence type 131

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