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Role of potassium channels in female reproductive system

Obstetrics & Gynecology Science 2020년 63권 5호 p.565 ~ 576
김준모, 송기성, Xu Boqun, Wang Tong,
소속 상세정보
김준모 ( Kim Jun-Mo ) - Soonchunhyang University Bucheon Hospital Department of Urology
송기성 ( Song Ki-Sung ) - Soonchunhyang University Bucheon Hospital Interdisciplinary Program in Biomedical Science
 ( Xu Boqun ) - Yale University School of Medicine Department of Cellular and Molecular Physiology
 ( Wang Tong ) - Yale University School of Medicine Department of Cellular and Molecular Physiology

Abstract


Potassium channels are widely expressed in most types of cells in living organisms and regulate the functions of a variety of organs, including kidneys, neurons, cardiovascular organs, and pancreas among others. However, the functional roles of potassium channels in the reproductive system is less understood. This mini-review provides information about the localization and functions of potassium channels in the female reproductive system. Five types of potassium channels, which include inward-rectifying (Kir), voltage-gated (Kv), calcium-activated (KCa), 2-pore domain (K2P), and rapidly-gating sodium-activated (Slo) potassium channels are expressed in the hypothalamus, ovaries, and uterus. Their functions include the regulation of hormone release and feedback by Kir6.1 and Kir6.2, which are expressed in the luteal granulosa cells and gonadotropin-releasing hormone neurons respectively, and regulate the functioning of the hypothalamus-pituitary-ovarian axis and the production of progesterone. Both channels are regulated by subtypes of the sulfonylurea receptor (SUR), Kir6.1/SUR2B and Kir6.2/SUR1. Kv and Slo2.1 affect the transition from uterine quiescence in late pregnancy to the state of strong myometrial contractions in labor. Intermediate- and small-conductance KCa modulate the vasodilatation of the placental chorionic plate resistance arteries via the secretion of nitric oxide and endothelium-derived hyperpolarizing factors. Treatment with specific channel activators and inhibitors provides information relevant for clinical use that could help alter the functions of the female reproductive system.

키워드

Potassium channels; Gonadal steroid hormones; Ovary; Uterus; Placenta

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