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Association between decreased ovarian reserve and poor oocyte quality

Obstetrics & Gynecology Science 2021년 64권 6호 p.532 ~ 539
Scantamburlo Viviane Margareth, von Linsingen Renate, Centa Lidio Jair Ribas, Toso Kahisa Fontana Dal, Scaraboto Debora, Araujo Edward Junior, Kulak Jaime Junior,
소속 상세정보
 ( Scantamburlo Viviane Margareth ) - Human Reproduction and Andrology Clinic and Laboratory Department Gynecology and Obstetrics
 ( von Linsingen Renate ) - Human Reproduction and Andrology Clinic and Laboratory Department Gynecology and Obstetrics
 ( Centa Lidio Jair Ribas ) - Human Reproduction and Andrology Clinic and Laboratory Department Gynecology and Obstetrics
 ( Toso Kahisa Fontana Dal ) - Human Reproduction and Andrology Clinic and Laboratory Department Gynecology and Obstetrics
 ( Scaraboto Debora ) - Human Reproduction and Andrology Clinic and Laboratory Department Gynecology and Obstetrics
 ( Araujo Edward Junior ) - Federal University of Sao Paulo Paulista School of Medicine Department of Obstetrics
 ( Kulak Jaime Junior ) - Federal University of Parana Department of Obstetrics and Gynecology

Abstract


Objective: To analyze the association between oocyte quality and decreased ovarian reserve (DOR) markers in young women undergoing controlled ovarian stimulation (COS).

Methods: This retrospective study included 49 patients classified as having DOR based on anti-Mullerian hormone (AMH) levels, follicle-stimulating hormone (FSH) levels, or antral follicle counts (AFCs; <10). Images of all obtained oocytes were analyzed, and oocyte quality was classified according to maturity and morphology. The COS protocol utilized gonadotropin (FSH and/or human menopausal gonadotropin [hMG]) doses ranging from 150 to 300 IU/day. The Student’s t test or Mann-Whitney test was used to compare the groups. Spearman’s coefficients were estimated to verify the correlation between the administered dose of FSH/hMG and the number of mature oocytes. To evaluate the association between patient- and oocyte-related variables, logistic regression models were adjusted.

Results: Women with DOR classified according to FSH level had more immature oocytes (P<0.001). Women with DOR according to AMH had fewer mature oocytes and increased basal FSH levels (P<0.001). Women with DOR according to AFC had an increased risk of abnormally shaped oocytes (P=0.035).

Conclusion: This study showed that DOR based on AMH levels, FSH levels, and AFC was associated with poorer quality oocytes in young women who underwent COS.

키워드

Infertility; Oocyte quality; Ovarian reserve; Controlled ovarian stimulation; Decreased ovarian reserve

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