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Oral health management of a patient with tuberous sclerosis complex for oral mucositis under everolimus

대한장애인치과학회지 2020년 16권 1호 p.42 ~ 47
Suzuki Hitomi, Matsuo Koichiro,
소속 상세정보
 ( Suzuki Hitomi ) - Fujita Health University School of Medicine Department of Dentistry and Oral-Maxillofacial Surgery
 ( Matsuo Koichiro ) - Fujita Health University School of Medicine Department of Dentistry and Oral-Maxillofacial Surgery

Abstract


Introduction: Recently, everolimus has been used as a treatment for subependymal giant cell astrocytomas and renal angiomyolipoma in patients with tuberous sclerosis. Oral everolimus application often causes oral mucositis. However, dentists and dental hygienists do not yet fully understand the adverse events and how to deal with them. This report aimed to describe the successful oral health management of a tuberous sclerosis complex (TSC) patient with oral mucositis under everolimus.

Case presentation: A 26-year-old man with TSC was referred by a urologist to our dental outpatient clinic for oral examination before commencing oral everolimus for the treatment of renal angiomyolipoma. Other TSC comorbidities included subependymal giant cell astrocytomas, epilepsy, and severe mental retardation. His oral condition was poor since he had not visited a dental office for an extended time due to extremely uncooperative behavior. Periodontal and caries treatments were carried out under behavior management techniques and immobilization by his mother and dental staff. Proper management of oral mucositis and oral care procedures were also instructed to the mother. His oral hygiene status improved and multiple oral mucositis lesions by everolimus did not deteriorate to cause infection or delayed healing.

Conclusion: To prevent the deterioration of oral hygiene and oral mucositis by medication, dental professionals should be involved in a team-based approach to TSC treatment.

키워드

Tuberous sclerosis complex; Oral mucositis; Oral health management; Everolimus

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