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Severe Thrombocytopenia in a Patient with COVID-19

Infection & Chemotherapy 2020년 52권 3호 p.410 ~ 414
Nham Eliel, 고재훈, 정병호, 허경민, 조선영, 강철인, 정두련, 백경란,
소속 상세정보
 ( Nham Eliel ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Medicine
고재훈 ( Ko Jae-Hoon ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Medicine
정병호 ( Jeong Byeong-Ho ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Medicine
허경민 ( Huh Kyung-Min ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Medicine
조선영 ( Cho Sun-Young ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Medicine
강철인 ( Kang Cheol-In ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Medicine
정두련 ( Chung Doo-Ryeon ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Medicine
백경란 ( Peck Kyong-Ran ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Medicine

Abstract


Coronavirus disease 2019 (COVID-19) outbreak is spreading rapidly all over the world, being a major threat to public health. Since clinical feature of COVID-19 has not been fully evaluated yet, empirical antibacterial agents are frequently combined for the treatment of COVID-19 in addition to antiviral agents, concerning co-existing bacterial pathogens. We experienced a case of severe thrombocytopenia with epistaxis and petechiae, while treating a COVID-19 patient with ceftriaxone, levofloxacin, and lopinavir/ritonavir. The platelet count decreased to 2,000/mm3 and recovered after discontinuation of the three suspected drugs. In treating a potentially fatal emerging infectious disease, empirical and/or experimental approach would be unavoidable. However, the present case suggests that the possibility of adverse effects caused by polypharmacy should also be carefully considered.

키워드

COVID-19; Lopinavir/ritonavir; Ceftriaxone; Levofloxacin; Thrombocytopenia

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