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Recurrent Campylobacter Bacteremia as the First Manifestation of Hypogammaglobulinemia: a Case Report and Literature Review

Infection & Chemotherapy 2020년 52권 3호 p.415 ~ 420
Gharamti Amal A., Moukalled Nour, Taher Ali, Kanafani Zeina A.,
소속 상세정보
 ( Gharamti Amal A. ) - American University of Beirut Medical Center Department of Internal Medicine
 ( Moukalled Nour ) - American University of Beirut Medical Center Department of Internal Medicine
 ( Taher Ali ) - American University of Beirut Medical Center Department of Internal Medicine
 ( Kanafani Zeina A. ) - American University of Beirut Medical Center Department of Internal Medicine

Abstract


A 30-year-old woman with a past medical history of autoimmune hemolytic anemia presented with fever. Blood cultures grew Campylobacter. Her medical history was significant for four prior episodes of Campylobacter gastroenteritis and bacteremia. She received ciprofloxacin for the index presentation, then Meropenem de-escalated to doxycycline 6 months later following recurrence of Campylobacter. This prompted investigation for an immunodeficiency disorder. She was found to have hypogammaglobulinemia. Her Campylobacter infections resolved following the administration of intravenous immunoglobulins every 3 weeks. She did not have recurrence of Campylobacter during 5 years of follow-up. A literature search revealed additional four case reports of six hypogammaglobulinemic adult individuals presenting with recurrent Campylobacter infections. Three patients were already on intravenous immunoglobulin (IVIG) when Campylobacter infection occurred, and two patients achieved clinical cure following therapy with imipenem and IVIG. This case report highlights the importance of suspecting hypogammaglobulinemia in patients with recurrent Campylobacter infections, as this is sometimes the first manifestation of the condition.

키워드

Campylobacter; Hypogammaglobulinemia; Immunodeficiency; Bacteremia

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