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Successful Management of Pan-Resistant Acinetobacter baumannii Meningitis without Intrathecal or Intraventricular Antibiotic Therapy in a Neonate

Infection & Chemotherapy 2021년 53권 1호 p.146 ~ 150
Sayyahfar Shirin, Choobdar Farhad Abolhasan, Mashayekhi Mahdi, Jazi Faramarz Masjedian,
소속 상세정보
 ( Sayyahfar Shirin ) - Iran University of Medical Sciences Institute of Immunology and Infectious Diseases Research Center of Pediatric Infectious Diseases
 ( Choobdar Farhad Abolhasan ) - Iran University of Medical Sciences
 ( Mashayekhi Mahdi ) - Tehran University of Medical Sciences
 ( Jazi Faramarz Masjedian ) - Iran University of Medical Sciences School of Medicine Department of Microbiology

Abstract


Acinetobacter baumannii is one of the most important etiologies of nosocomial infections in recent years mainly because of increasing in frequency of multidrug and pan-resistant pathogens. Meningitis caused by this organism is a dilemma; because polymyxins are the only effective antibiotics against pan-resistant serotypes, but have poor penetration via blood brain barrier; however, it has still remained uncertain whether the intravenous therapy with these agents is an effective treatment with the sufficient concentration of the drug in the cerebrospinal fluid. Herein, we report a neonate who suffered from pan-resistant A. baumannii nosocomial meningitis successfully treated with intravenous colistin combined with meropenem and rifampin. It seems that intravenous colistin at least in combination with rifampin and meropenem might be considered as an option to try in patients in whom daily intrathecal injection or insertion of intraventricular device is not possible.

키워드

Acinetobacter baumannii; Colistin; Meningitis; Multi-drug resistant; Neonate, Polymyxin

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