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Effects of Omega-3 Fatty Acid on Endotoxin-induced Acute Lung Injury in Rabbits

Biomedical Science Letters 2021년 27권 1호 p.19 ~ 27
장은아, 손성국, 강정현, 이성헌, 곽상현,
소속 상세정보
장은아 ( Jang Eun-Ah ) - Chonnam National University Medical School Department of Anesthesiology and Pain Medicine
손성국 ( Son Sung-Kuk ) - Chonnam National University Medical School Department of Anesthesiology and Pain Medicine
강정현 ( Kang Jeong-Hyeon ) - Chonnam National University Medical School Department of Anesthesiology and Pain Medicine
이성헌 ( Lee Seong-Heon ) - Chonnam National University Medical School Department of Anesthesiology and Pain Medicine
곽상현 ( Kwak Sang-Hyun ) - Chonnam National University Medical School Department of Anesthesiology and Pain Medicine

Abstract


This study was undertaken to clarify the effects of omega-3 fatty acid on endotoxin-induced acute lung injury. Rabbits were randomly assigned to one of four groups. Each group received intravenous infusion of saline only, saline and Escherichia coli endotoxin, omegaven infuison (0.5 mL/kg/hr) and endotoxin, lipoven (0.5 mL/kg/hr) and endotoxin respectively. Infusion of saline was started 0.5 hr before the infusion of saline or endotoxin, and omegaven and lipoven were started 2 hours after endotoxin infusion for 4 hours. The lungs of rabbits were ventilated with 40% oxygen. Mean blood pressure, heart rate, arterial oxygen tension (PaO2), and peripheral blood leukocyte were recorded. The wet/dry (W/D) weight ratio of lung and lung injury score were measured, and analysis of bronchoalveolar lavage fluid (BALF) was done. Endotoxin decreased PaO2, and peripheral blood leukocyte and platelet count. And it increased W/D ratio of lung, lung injury score and leukocyte count, percentage of PMN cells, concentration of IL-8 in BALF. Omegaven attenuated all these changes except for peripheral blood leukocyte counts. Omegaven attenuated endotoxin-induced acute lung injury in rabbits mainly by inhibiting neutrophil and IL-8 responses, which may play a central role in endotoxin-related lung injury.

키워드

Acute lung injury; Endotoxins; Systemic inflammatory response syndrome; Omegaven

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