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Proliposome powder or tablets for generating inhalable liposomes using a medical nebulizer

Journal of Pharmaceutical Investigation 2021년 51권 1호 p.61 ~ 73
Khan Iftikhar, Yousaf Sakib, Najlah Mohammad, Ahmed Waqar, Elhissi Abdelbary,
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 ( Khan Iftikhar ) - Liverpool John Moores University School of Pharmacy and Biomolecular Sciences
 ( Yousaf Sakib ) - University of Central Lancashire School of Pharmacy and Biomedical Sciences
 ( Najlah Mohammad ) - Anglia Ruskin University Faculty of Health, Education, Medicine and Social Care School of Allied Health Pharmaceutical Research Group
 ( Ahmed Waqar ) - University of Lincoln College of Science School of Mathematics and Physics
 ( Elhissi Abdelbary ) - Qatar University College of Pharmacy

Abstract


Purpose: The aim of this study was to develop and compare proliposome powder and proliposome tablet formulations for drug delivery from a Pari-LC Sprint nebulizer.

Methods: Proliposome powders were prepared by the slurry method and sorbitol or mannitol carbohydrate carrier were used in a 1:10 and 1:15 w/w lipid phase to carrier ratio. Beclometasone dipropionate (BDP; 2 mol%) was incorporated in the lipid phase. Proliposome powders were compressed into tablets, and liposomes were generated from proliposome powders or tablets within the nebulizer reservoir for subsequent aerosolization.

Results: Comparatively, shorter sputtering times were reported for the tablet formulations (??
Conclusion: Overall, this study showed that proliposome tablets could be disintegrated within a Pari-LC Sprint nebulizer to generate inhalable aerosol, with high drug output and hence can be manufactured on large scale to overcome the storage problems associated with powder formulations.

키워드

Liposome; Proliposome; Jet-nebulizer; Two-stage impinger; Beclometasone dipropionate; Tablets

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