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Ameliorative potential of Sterculia tragacantha aqueous extract on renal gene expression and biochemical parameters in streptozotocin-induced diabetic rats

Journal of Pharmaceutical Investigation 2021년 51권 1호 p.103 ~ 113
Ajiboye Basiru Olaitan, Oyinloye Babatunji Emmanuel, Essien Precious Ekong, Onikanni Sunday Amos, Ojo Oluwafemi Adeleke, Kappo Abidemi Paul,
소속 상세정보
 ( Ajiboye Basiru Olaitan ) - Afe Babalola University Department of Biochemistry
 ( Oyinloye Babatunji Emmanuel ) - Afe Babalola University Department of Biochemistry
 ( Essien Precious Ekong ) - Afe Babalola University Department of Biochemistry
 ( Onikanni Sunday Amos ) - Afe Babalola University Department of Biochemistry
 ( Ojo Oluwafemi Adeleke ) - Landmark University Department of Biochemistry
 ( Kappo Abidemi Paul ) - University of Johannesburg Faculty of Science Department of Biochemistry

Abstract


Purpose: The ameliorative potential of aqueous leave extract of Sterculia tragacantha on renal gene expression and biochemical parameters in streptozotocin-induced diabetic rats were assessed.

Methods: Forty albino rats (out of fifty) were intraperitoneally induced using 35 mg/kg of streptozotocin, and then grouped into normal control, diabetic control, diabetic animals received 150 and 300 mg/kg of aqueous extract of S. tragacantha leaves (AESTL) and diabetic animals placed on 200 mg/kg of metformin. This experiment lasted for two weeks, animals were sacrificed, and a series of biochemical indices were evaluated.

Results: Diabetic rats receiving AESTL revealed a momentous decline in fasting blood glucose, urea, creatinine, uric acid, and alkaline phosphatase levels. Administration of AESTL to diabetic animals considerably improved the activities of SOD, CAT, GPx, GST, and GSH with a decline in MDA levels. Also, AESTL reversed abnormalities in mRNA gene expressions of IL-1β, TGF-1β, KIM-1, EPO and CASP 6 in diabetic rats placed on AESTL treatment. The excellent results of diabetic rats maintained on AESTL were supported by histological findings in this study.

Conclusion: Hence, AESTL may have beneficial effects in controlling nephropathy associated with diabetes mellitus.

키워드

Anti-nephropathy; mRNA gene expression; Management; Diabetic

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