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Development of a zero-order kinetics drug release floating tablet with anti?flip-up design fabricated by 3D-printing technique

Journal of Pharmaceutical Investigation 2021년 51권 2호 p.213 ~ 222
Huanbutta Kampanart, Sriamornsak Pornsak, Kittanaphon Thanayoth, Suwanpitak Kittipat, Klinkesorn Natdanai, Sangnim Tanikan,
소속 상세정보
 ( Huanbutta Kampanart ) - Burapha University Faculty of Pharmaceutical Sciences
 ( Sriamornsak Pornsak ) - Silpakorn University Faculty of Pharmacy Department of Pharmaceutical Technology
 ( Kittanaphon Thanayoth ) - Burapha University Faculty of Pharmaceutical Sciences
 ( Suwanpitak Kittipat ) - Burapha University Faculty of Pharmaceutical Sciences
 ( Klinkesorn Natdanai ) - Burapha University Faculty of Pharmaceutical Sciences
 ( Sangnim Tanikan ) - Burapha University Faculty of Pharmaceutical Sciences

Abstract


Purpose: Helicobacter pylori is a common cause of peptic ulcer disease, but patient’s low compliance to treatment can cause antibiotic resistance. The aim of the study was to describe a gastroretentive drug delivery system using an anti?flip-up floating tablet design prepared by using 3D printing with the goal of achieving better therapeutic outcomes.

Methods: Polylactic acid (PLA) was the printing material for the floating tablet housing, with metronidazole as the model drug. The core tablet was prepared by direct compression and placed in the middle of the housing. The floating system was optimized by using a Box?Behnken experimental design with core tablet main factors of drug release orifice, air volume (height was varied), and compression force. The optimized formulation was prepared to test the prediction efficiency of the model.

Results: The optimized model required a drug release orifice of 23.10 mm2, air compartment height of 2.0 mm, and compression force of 3.63 tons, providing constant drug release for 8 h (average R2?=?0.9920). The optimized anti?flip-up tablets did not flip-up during the test.

Conclusion: This gastroretentive drug release model shows possibility for constant extended drug dissolution which could enhance therapeutic efficiency of peptic ulcer disease from Helicobacter pylori.

키워드

Floating drug delivery systems; 3D-printing; Zero-order kinetics drug release; Helicobacter pylori

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