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High-Efficiency Cationic Labeling Algorithm of Macroaggregated Albumin with 68Gallium

Nuclear Medicine and Molecular Imaging 2021년 55권 2호 p.79 ~ 85
Ayse Ugur, Aziz Gultekin, Dogangun Yuksel,
소속 상세정보
 ( Ayse Ugur ) - Pamukkale University Department of Nuclear Medicine
 ( Aziz Gultekin ) - Pamukkale University Department of Nuclear Medicine
 ( Dogangun Yuksel ) - Pamukkale University Department of Nuclear Medicine

Abstract


Purpose: The generator product radionuclide gallium-68(68Ga) is widely used for PET/CT imaging agents and the 68Ga-labeled MAA is an attractive alternative to 99mTc-labeled MAA. Using a commercially available MAA labeling kit for 99mTc, we presented a reliable synthesis protocol with a highly efficient, organic solvent-free cationic method in GMP conditions in the Scintomics automated synthesis unit.

Methods: The labeling process was performed by incubating for 7 min at 90 °C in the borax vial containing the generator product 68GaCl3 MAA-HEPES eluted from the PSH+ cartridge with 1.5 mL 5 molar NaCl. Quality control of the final product content was examined, and radiopharmaceutical production was carried out in accordance with GMP guidelines.

Results: 68Ga eluted from the generator was obtained in more than 99% radiochemical purity and efficiency. In this case, the labeling efficiency was found to be >99%. When the results of SEM-EDX analysis in the final product were examined, it was determined that most of toxic metals were no appreciable in the product content.

Conclusions: The radiochemical and chemical purity of the final product allows direct use without purification steps to remove “free 68Ga” or other toxic compounds.

키워드

Gallium-68; MAA; Macroaggregated albumin; Positron emission tomography; Radiopharmaceutical; Lung perfusion scintigraphy

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