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파어탕의 L-NAME 유도 고혈압 동물군에서의 혈압강하효과 및 심신기능 개선 효과

Beneficial effects of Paeo-tang on cardiovascular and renal function in L-NAME-induced hypertensive rats

대한한의학방제학회지 2020년 28권 3호 p.271 ~ 280
나세원, 홍미현, 김혜윰, 장윤재, 윤정주, 이윤정, 강대길, 이호섭,
소속 상세정보
나세원 ( Na Se-Won ) - Wonkwang University College of Oriental Medicine Department of Physiology
홍미현 ( Hong Mi-Hyeon ) - Wonkwang University College of Oriental Medicine Department of Physiology
김혜윰 ( Kim Hye-Yoom ) - Wonkwang University College of Oriental Medicine Department of Physiology
장윤재 ( Jang Youn-Jae ) - Wonkwang University College of Oriental Medicine Department of Physiology
윤정주 ( Yoon Jung-Joo ) - Wonkwang University College of Oriental Medicine Department of Physiology
이윤정 ( Lee Yun-Jung ) - Wonkwang University College of Oriental Medicine Department of Physiology
강대길 ( Kang Dae-Gill ) - Wonkwang University College of Oriental Medicine Department of Physiology
이호섭 ( Lee Ho-Sub ) - Wonkwang University College of Oriental Medicine Department of Physiology

Abstract


Hypertension has been approved to cause disharmony between the heart and kidney such as cardiac hypertrophy and kidney dysfunction. In traditional oriental medicine Paeo-tang (PET) has been shown to have effects on blood circulation improvement. However, the beneficial effect of PET on hypertension remains unknown. In this study, we investigated that PET attenuates blood pressure and improves cardiovascular and renal function in NG-nitro-L-arginine methylester (L-NAME) rat model. Hypertensive rat models were induced by the administration of L-NAME (40 mg/kg/day) and then PET (50 or 100 mg/kg/day) or Olmetec was treated for 2 weeks. PET treatment significantly suppressed the systolic blood pressure and decreased intima-media thickness in the thoracic aorta. PET ameliorated endothelium-dependent and independent vascular relaxation in the L-NAME-induced vascular dysfunction. PET ameliorated the functional decline in the kidney such as albumin and blood urea nitrogen in plasma. These results demonstrated that PET possesses protective effects against L-NAME-induced hypertension.

키워드

Paeo-tang; L-NAME; Hypertension; renal dysfunction

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