잠시만 기다려 주세요. 로딩중입니다.

丹參을 뇌졸중 동물모델에 적용하기 위한 기초적인 네트워크 약리학 분석

Basic network pharmacological analysis of Salvia miltiorrhiza root for further application to an animal stroke model

대한한의학방제학회지 2021년 29권 1호 p.19 ~ 31
최명진, 양원진, 이병호, 조수인,
소속 상세정보
최명진 ( Choi Myeong-Jin ) - Pusan National University School of Korean Medicine
양원진 (  ) - Pusan National University School of Korean Medicine
이병호 ( Lee Byoung-Ho ) - Injoo Hospital of Korean Medicine
조수인 ( Cho Su-In ) - Pusan National University School of Korean Medicine

Abstract


Objectives : The root of Salvia miltiorrhiza, known as ‘Dansam (DS, 丹參)’, is used for and treating cardiovascular diseases based on its efficacy of promoting blood circulation and breaking through a blood stasis. In this study, we would like to see if DS could be effectively used for stroke from the perspective of network pharmacology.

Methods : The analysis was conducted using Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) database to derive the main active compounds of DS and identify the mechanism of each compound acting on the human body. The networks between compounds, target protein and disease were expressed through Cytoscape. Protein-protein interaction (PPI) analysis was performed using STRING database.

Results : Fifty two active compounds of DS were identified by screening the ingredients of DS through TCMSP. Based on the networks of these compounds with target protein and disease, it can be said that DS might be effective for preventing and treating stroke. PPI result showed that adrenergic receptor has many interactions among proteins, indicating its significance in stroke pathway.

Conclusion : In this study, we derived target proteins and target diseases of DS that could be used in study of stroke. However, since it is uncertain if these targets can be controlled by DS extracts or not, we would like to confirm the results with further animal experiments.

키워드

Salviae Miltiorrhizae Radix; ischemic stroke; systems biology

원문 및 링크아웃 정보

등재저널 정보