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Efficacy of herbal medicine (Xuanfei Baidu decoction) combined with conventional drug in treating COVID-19:A pilot randomized clinical trial

Integrative Medicine Research 2020년 9권 3호 p.13 ~ 13
Xiong Wu-Zhong, Wang Gang, Du Juan, Ai Wang,
소속 상세정보
 ( Xiong Wu-Zhong ) - Wuhan Hospital of Traditional Chinese Medicine
 ( Wang Gang ) - Wuhan Hospital of Traditional Chinese Medicine
 ( Du Juan ) - Wuhan Pulmonary Hospital
 ( Ai Wang ) - Wuhan Hospital of Traditional Chinese Medicine

Abstract


Background: The aim of this study was to evaluate the clinical efficacy of Xuanfei Baidu Decoction (XBD) combined with conventional drug therapy compared with conventional medicine alone in patients with coronavirus disease 2019 (COVID-19).

Methods: Forty-two patients with COVID-19 were randomly assigned to XBD plus conventional medicine (n = 22) and conventional medicine alone (n = 20). Both groups were treated for 1 week. The primary endpoint was the disappearance rate of main symptoms (fever, cough, and fatigue).

Results: Compared with the conventional medicine, the disappearance rate of clinical symptoms such as fever, cough, fatigue and loss of appetite in the experimental group were significantly reduced (P < 0.05). The number of white blood cells and lymphocytes in the experimental group increased significantly (P < 0.05), which all returned to normal parameters. Meanwhile, the C-reactive protein and erythrocyte sedimentation rate in the experimental group were significantly reduced (P < 0.05).

Conclusion: XBD combined with conventional medicine may significantly improve patient's clinical symptoms, increase the number of white blood cells and lymphocytes to improve immunity, and also significantly reduce C-reactive protein and erythrocyte sedimentation rate to play an anti-inflammatory effect. However, it needs to be confirmed by a large sample study.

키워드

COVID-19; Herbal medicine; Randomized controlled trial; Integrative medicine; Chinese medicine

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