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Rapid review protocol: Zinc for the prevention or treatment of COVID-19 and other coronavirus-related respiratory tract infections

Integrative Medicine Research 2020년 9권 3호 p.19 ~ 19
Hunter Jennifer, Arentz Susan, Goldenberg Joshua Z., Yang Guoyan, Beardsley Jennifer, Mertz Dominik, Leeder Stephen,
소속 상세정보
 ( Hunter Jennifer ) - Western Sydney University NICM Health Research Institute
 ( Arentz Susan ) - Western Sydney University NICM Health Research Institute
 ( Goldenberg Joshua Z. ) - National University of Natural Medicine Helfgott Research Institute
 ( Yang Guoyan ) - Western Sydney University NICM Health Research Institute
 ( Beardsley Jennifer ) - Western Sydney University NICM Health Research Institute
 ( Mertz Dominik ) - McMaster University Department of Medicine
 ( Leeder Stephen ) - University of Sydney Faculty of Medicine and Health Sydney School of Public Health

Abstract


Background: The global COVID-19 pandemic has prompted an urgent search for effective interventions. SARS-CoV-2 mortality/morbidity risk increases with age and for those chronic disease co-morbidities, both of which are associated with lower zinc status, as is the risk of infection.

Methods: Rapid review methods will be applied to a systematic review of zinc for the prevention or treatment of SARS-CoV-2 and viral respiratory tract infections in humans. Included are published studies reporting randomised and quasi-randomised controlled trials that compare zinc intervention to placebo and/or other comparator interventions. English and Chinese language databases will be searched for primary studies of viral respiratory tract infections and clinical trial registries for SARS-CoV-2 infections. Due to concerns about indirectness, studies evaluating non-SARS-CoV-2 coronavirus infections will be rated down by one level, and non-specific or confirmed non-coronavirus viral infections will be rated down by two levels. Review constraints include (1) using Google translate when screening articles published in languages other than English or Chinese and limited translation (2) following calibration, only one reviewer will screen articles, extract data, appraise quality and conduct the analysis, (3) prioritising data extraction and meta-analyses of SARS-CoV-2 studies and critical outcomes of other viral infections, followed by high risk groups and (4) reporting important preliminary findings prior to peer review if necessary.

Discussion: The application of these rapid review methods and broadening the inclusion criteria to include other coronavirus-related viral respiratory tract infections aims to enable a timely evidence appraisal of priority research questions and dissemination of results.

키워드

SARS-CoV-2; Coronavirus; Rapid review; Respiratory tract infection; Zinc

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