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Efficacy and safety of herbal medicine (Lianhuaqingwen) for treating COVID-19: A systematic review and meta-analysis

Integrative Medicine Research 2021년 10권 1호 p.8 ~ 8
Liu Ming, Gao Ya, Yuan Yuan, Yang Kelu, Shi Shuzhen, Tian Jinhui, Zhang Junhua,
소속 상세정보
 ( Liu Ming ) - Lanzhou University School of Basic Medical Sciences Evidence-Based Medicine Center
 ( Gao Ya ) - Lanzhou University School of Basic Medical Sciences Evidence-Based Medicine Center
 ( Yuan Yuan ) - Gansu University of Chinese Medicine
 ( Yang Kelu ) - Lanzhou University School of Nursing Evidence-Based Nursing Center
 ( Shi Shuzhen ) - Lanzhou University School of Basic Medical Sciences Evidence-Based Medicine Center
 ( Tian Jinhui ) - Lanzhou University School of Basic Medical Sciences Evidence-Based Medicine Center
 ( Zhang Junhua ) - Tianjin University of Traditional Chinese Medicine Evidence-Based Medicine Center

Abstract


Background: Lianhuaqingwen (LH) has been proven effective for influenza. However, the promotion of LH for the treatment of patients with COVID-19 remains controversial. Therefore, our study aimed to assess the efficacy and safety of Lianhuaqingwen (LH) in treating patients with COVID-19 by a systematic review and meta-analysis.

Methods: We conducted the literature search using six electronic databases from December 1, 2019, to June 2, 2020. Cochrane Risk of Bias tool was used to assess the quality of randomized controlled trials. Newcastle-Ottawa Scale was used to assess the quality of case control studies. Agency for Healthcare Research and Quality checklist was used to assess the quality of case series. All analyses were conducted by RevMan 5.3. For outcomes that could not be meta-analyzed were performed a descriptive analysis.

Results: Eight studies with 924 patients were included. Three studies were RCTs, three were case control studies, and two were case series. The quality of the included studies was poor. Compared with patients treated by conventional treatment, patients treated by LH combined with conventional treatment have a higher overall effective rate (RR?=?1.16, 95%CIs: 1.04∼1.30, P?=?0.01) and CT recovery rate (RR=1.21, 95%CIs: 1.02∼1.43, P?=?0.03). Patients of LH groups have a lower incidence of diarrhea (5.6% vs.13.4%), and have statistically significant (P?=?0.026). But the rate of abnormal liver function in the combined medication group is higher than that in the single LH group.

Conclusion: LH combined with conventional treatment seems to be more effective for patients with mild or ordinary COVID-19.

키워드

COVID-19; Lianhuaqingwen; Herbal medicine; Systematic review; Meta-analysis

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