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Association between Atherogenic Index of Plasma and the Risk of Obstructive Sleep Apnea in Korean Adults Who Admitted to the Sleep Clinic

Chronobiology in Medicine 2020년 2권 4호 p.170 ~ 174
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Abstract


Objective: Atherogenic index of plasma (AIP) is closely related to insulin resistance, which is a major characteristics of obstructive sleep apnea (OSA). However, data on the association between AIP and OSA has been limited. This study evaluated the association of AIP with OSA.

Methods: AIP was assessed in 180 consecutive Korean adults with suspected OSA who admitted to the sleep clinic between 2010 and 2012. OSA was defined as the occurrence of more than 5 apnea-hypopnea index (AHI) events/h. All participants were divided into three groups according to the AIP tertiles, which were determined by the log of (triglyceride/high-density lipoprotein cholesterol).

Results: The prevalence of OSA increased [group I (lowest): 73.8%; group II: 86.4%; group III (highest): 91.7%] as increasing AIP tertiles (p=0.022). AIP had a positive correlation with AHI (r=0.210; p=0.005). In univariate linear regression analysis, AIP (per 0.1-unit increase) was significantly related to AHI (β=2.460; p=0.005). Univariate logistic regression analysis showed that AIP was associated with an increased risk of OSA [odds ratio (OR): 1.450; 95% confidence interval (CI): 1.179?1.785; p<0.001]. However, this association was attenuated after adjusting for multiple risk factors including age, male sex, alcohol consumption, obesity, and smoking (OR: 1.252; 95% CI: 0.995?1.575; p=0.055).

Conclusion: Despite a significant correlation of AIP with AHI, AIP was not an independent predictive marker for OSA beyond multiple risk factors. Further investigation with larger sample size might be necessary.

키워드

Atherogenic index of plasma; Obstructive sleep apnea; Apnea-hypopnea index

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